Search for dissertations about: "DAS28"

Showing result 1 - 5 of 17 swedish dissertations containing the word DAS28.

2. 1. B cell subpopulations in the pathogenesis of rheumatoid arthritis

   Author : Katrin Thorarinsdottir; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cells; Rheumatoid arthritis; Joint destruction; DAS28; CD21- low B cells;

   Abstract : B cell depleting therapy has proven to be an effective treatment in rheumatoid arthritis (RA), a disease characterized by the presence of autoantibodies against citrullinated proteins (ACPA) and the Fc portion of IgG (rheumatoid factor, RF). This demonstrates the vital role B cells play in the disease. READ MORE

4. 2. Exploring a national practice-based register for the management of rheumatoid arthritis

   Author : Cheryl Carli; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Rheumatoid arthritis (RA) is a chronic, inflammatory, auto-immune disease with an unpredictable and debilitating course. From diagnosis and onward, RA patients who need treatment with anti-rheumatic drugs will require on-going contact with health care professionals to ensure adequate management of their disease. READ MORE

5. 3. Health economics and its measures in rheumatoid arthritis

   Author : Johan Karlsson; Reumatologi och molekylär skelettbiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cost-utility analysis; Cost-of-illness; Quality of life; EuroQol 5-Dimensions; Antirheumatic agents; TNF inhibition; Outcome assessment; Disease activity; Disability; Health economics; Rheumatoid arthritis;

   Abstract : Objectives: To study: (I) the impact on cost-utility analyses of applying different national EuroQol 5-Dimensions (EQ-5D) preference sets; (II and III) whether, in methotrexate-refractory, early rheumatoid arthritis (RA), the addition of infliximab results in superior health-related quality of life (HRQoL) and may be considered cost-effective, as compared to adding sulfasalazine and hydroxychloroquine; (IV) how costs relate to disability (measured by the health-assessment questionnaire, HAQ), disease activity (28-joint disease activity score, DAS28) and HRQoL (EQ-5D) in RA. Methods: In the observational SSATG register, one-year quality-adjusted life-year (QALY) accumulation of two interventions was compared according to the UK, US, or Danish EQ-5D preference sets. READ MORE

6. 4. Pain patterns in early rheumatoid arthritis

   Author : Joakim Lindqvist; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Study I: Widespread non-joint pain in early rheumatoid arthritis. Objective: The aim of the study was to assess the development of widespread non-joint pain (WNP) in a cohort of patients with early rheumatoid arthritis (RA), the associated health-related quality of life (HRQoL), and clinical and demographical risk factors for WNP. READ MORE

7. 5. Rheumatoid arthritis in male patients : sex hormones, bone mineral density and clinical characteristics

   Author : Birgitta Tengstrand; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Rheumatoid arthritis; men; gender; testosterone; DHEAS; estrone; estradiol; LH; bone mineral density; outcome.;

   Abstract : The aims of this study were to investigate sex hormones in men with RA and the relation of these hormones with disease characteristics including bone mineral density, as well as to study gender differences in rheumatoid arthritis (RA). Estrogens and androgens and the balance between these hormones interact with the cytokine network and modulate immunity. READ MORE