Search for dissertations about: "DBL1alpha"

Found 3 swedish dissertations containing the word DBL1alpha.

2. 1. Development of a recombinant protein vaccine against Plasmodium falciparum malaria

   Author : Sanjay Ahuja; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Vaccine; Plasmodium falciparum; DBL1alpha ; cross-reactivity; E.coli; recombinant expression; soluble protein;

   Abstract : Malaria, caused by Plasmodium falciparum is one of the world´s deadliest diseases, killing one to two million children, while another 500 million suffer from clinical attacks every year. Infections caused by P. READ MORE

4. 2. Heparan sulfate dependent sequestration during Plasmodium falciparum malaria

   Author : Anna Vogt; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Severe malaria; Plasmodium falciparum; sequestration; endothelial adhesion; erythrocyte rosetting; PfEMP1; DBL1alpha; heparan sulfate; heparin; animal model.;

   Abstract : Plasmodium falciparum infected erythrocytes are able to bind to the microvascular endothelium (cytoadherence), and to uninfected erythrocytes (rosetting) that lead to excessive sequestration of the parasites. This causes obstruction of the deep microvasculature by P. READ MORE

5. 3. Sequestration, virulence, and future interventions in Plasmodium falciparum malaria

   Author : Fredrik Pettersson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Severe malaria; Plasmodium falciparum; sequestration; endothelial adhesion; erythrocyte rosetting; PfEMP1; DBL1alpha; animal model; vaccine; adjuvant treatment;

   Abstract : The Plasmodium falciparum infected erythrocyte (iRBC) withdraws from the peripheral circulation to hide in the deep microvasculature during maturation. This phenomena, referred to as sequestration, is believed to cause extensive clogging of the vessels and contribute to die development of severe malaria. READ MORE