Search for dissertations about: "DDR"

Showing result 11 - 15 of 27 swedish dissertations containing the word DDR.

  2. 11. Novel functions of SMG-1 in carcinogenesis

    Author : Evgenia Gubanova; Thomas Helleday; Andrei Gudkov; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molekylärgenetik; Molecular Genetics;

    Abstract : Damage to DNA can cause mutations leading to cancer, and the DNA damage response (DDR), leading to transient cell-cycle arrest, DNA repair, senescence and apoptosis, plays a role in preventing tumor formation. At the same time, agents that damage DNA are used as anticancer therapy. READ MORE

  4. 12. Ephrin and Eph-receptor growth factor signaling in non small cell lung cancer : identification of biomarkers and therapeutic targets

    Author : Ghazal Efazat; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Non-small cell lung cancer (NSCLC) is the main subtype of lung cancer (LC) and unfortunately it responds very poorly to conventional chemo- and radiotherapy (RT). Moreover, NSCLC is often diagnosed at a stage where metastases are found and only for a limited number of NSCLC tumors targeted therapies can be used as their oncogenic drivers remains elusive. READ MORE

  5. 13. DDRNoC: Dual Data-Rate Network-on-Chip

    Author : Ahsen Ejaz; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Network-on-Chip; On-Chip Interconnect; Dual Data-Rate; Multiprocessor System-on-Chip; Chip Multiprocessors; System-on-Chip;

    Abstract : Networks-on-Chip (NoCs) are becoming increasing important for the performance of modern multi-core system-on-chip. For various on-chip networks with virtual channel (VC) ow control, the slow control logic (VC and switch allocation logic) of the NoC routers limits the NoC clock period while their datapath (switch and link) possesses signifcant slack. READ MORE

  6. 14. Targeting Myc-driven tumours - BETing on ATR

    Author : Somsundar Veppil Muralidharan; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer arises from loss of function of tumour suppressors and/or gain of function mutations in proto-oncogenes that disrupt the delicate balance required for homeostatic cell division, resulting in uncontrolled cell proliferation. Oncogenic transformation of multifaceted proto-oncogene - transcription factor - MYC can give rise to cancers and it is found to be deregulated in more than 70% of the tumours. READ MORE

  7. 15. Ion homeostasis in control of stem cell proliferation

    Author : Shaimaa Abdelhady; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The ion homeostasis is critically maintained in all cells by a combined effort from various ion channels, transporters, pumps, and gap junctions. Ion fluxes are essential in excitable cells as they regulate the excitability of the cells and initiate and propagate action potentials. READ MORE