Search for dissertations about: "DDR"

Showing result 21 - 25 of 27 swedish dissertations containing the word DDR.

  2. 21. Characterization of chromatin mobility upon DNA damage in Arabidopsis thaliana

    Author : Anis Meschichi; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Plant cells are subject to high levels of DNA damage from dependence on sunlight for energy and the associated exposure to biotic and abiotic stresses. Double-strand breaks (DSBs) are a particularly deleterious type of DNA damage, potentially leading to chromosome rearrangements or loss of entire chromosome arms. READ MORE

  4. 22. Novel therapeutic targets in pediatric neural tumors

    Author : Jelena Milosevic; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The embryonal tumors neuroblastoma and medulloblastoma are two of the most common and deadliest tumors in childhood. Both are heterogeneous tumors that arise in the peripheral and central nervous system, respectively. READ MORE

  5. 23. Unwrapping the role of WRAP53β in DNA damage response

    Author : Hanif Rassoolzadeh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal body-specific (sca) RNAs and the telomerase enzyme to Cajal bodies, as well as targeting of the E3 ligase RNF8 to DNA double-strand breaks (DSBs). READ MORE

  6. 24. Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis

    Author : Siamak Akbari Kamranvar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : EBV;

    Abstract : EBV is associated with a variety of lymphoid and epithelial malignancies but the mechanisms of oncogenesis are still not fully understood. The aim of the work described in this thesis was to assess whether induction of genomic instability, as defined by the accumulation of non-clonal genetic aberrations, could play a role in EBV oncogenesis and identify the viral protein(s) responsible for this phenotype. READ MORE

  7. 25. Studies on early cellular responses during Epstein-Barr virus infection

    Author : Xinsong Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human gamma-herpesvirus Epstein-Barr virus (EBV) has been implicated in the pathogenesis of a broad spectrum of lymphoid and epithelial cell malignancies. A characteristic property of the virus is the capacity to establish a non-productive growthpromoting infection in B-lymphocytes. READ MORE