Search for dissertations about: "DEK-NUP214"
Found 2 swedish dissertations containing the word DEK-NUP214.
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1. Molecular Mechanisms of the DEK Protein in Leukemia
Abstract : The DEK gene is upregulated in a growing number of cancers and translocated to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. In this thesis, we studied the cellular and molecular functions of the DEK and DEK-NUP214 proteins. READ MORE
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2. On the role of the fusion protein DEK-NUP214 in leukemogenesis
Abstract : The t(6;9) translocation is found in a subset of patients with acute myeloid leukemia (AML) and is associated with a poor prognosis. The translocation results in the formation of the DEK-NUP214 fusion protein containing almost the entire nuclear protein DEK and two thirds of the nucleoporin NUP214. READ MORE