Search for dissertations about: "DFFA"

Found 5 swedish dissertations containing the word DFFA.

  2. 1. Identification and characterization of candidate genes for neuroblastoma development

    Author : Cecilia Krona; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cancer; tumor; child; embryonal; neural crest; neuroblastoma; chromosome 1; 1p36; mutation; expression; tumor suppressor gene; UBE4B; KIF1B; PGD; CORT; DFFA; PEX14; ICAT; CASP9; ENO1; MBP1; APITD1; PHOX2B;

    Abstract : Neuroblastoma (NB) is the most common tumor during infancy. It arises from undifferentiated cells in the sympathetic nervous system and is characterized by both clinical and genetic heterogeneity. One of the features of NBs with unfavorable outcome is loss on distal chromosome 1p. READ MORE

  4. 2. Microarray analysis of gene expression in human adipocytes and adipose tissue

    Author : Margareta Jernås; Göteborgs universitet; []
    Keywords : obesity; adipose tissue; insulin resistance; serum amyloid A; NAD P H:quinone oxidoreductase 1; Zinc-alpha2 glycoprotein; cell death-inducing DFFA-like effector A; DNA microarray;

    Abstract : Obesity has reached epidemic proportions worldwide and is associated with several serious conditions such as insulin resistance, type 2 diabetes, hyperlipidemia and atherosclerosis. Adipose tissue exerts important endocrine and immune functions through the release of adipokines. READ MORE

  5. 3. Genetic studies of neuroblastoma with emphasis on the apoptotic pathway

    Author : Frida Abel; Göteborgs universitet; []
    Keywords : child; cancer; neuroectodermal; neural crest; loss of heterozygosity; LOH; bcl-2; mcl-1; apaf-1; caspase-2; caspase-3; caspase-9; PIN; DLC-1; caspase-2;

    Abstract : Aim: The objective of this thesis was to find genes and chromosomal regions involved in neuroblastoma (NB) tumor progression. NB is a childhood tumor of the sympathetic nervous system that generally occurs spontaneously. READ MORE

  6. 4. Dietary effects on gene regulation and function in human adipose tissue in obesity

    Author : Elisabet Nordström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Obesity is an excess of body fat that develops from both genetic and environmental factors, leading to a disturbed balance between energy intake and energy expenditure. It is closely associated with insulin resistance, type 2 diabetes, hyperlipidemia and atherosclerosis. Its increasing prevalence has reached epidemic proportions worldwide. READ MORE

  7. 5. Fighting cardiometabolic disease : validation of new experimental models and therapeutic targets

    Author : Mirko Enea Minniti; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The prevalence of cardiometabolic diseases (CMD) such as atherosclerotic cardiovascular diseases, type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), has grown dramatically during the last decades. Hence, massive research efforts are allocated to identify the pathophysiological mechanisms and new therapeutic targets for these morbidities. READ MORE