Search for dissertations about: "DFG-out"
Found 2 swedish dissertations containing the word DFG-out.
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1. Using Light to Regulate the Activity of RET Kinase: Design, synthesis and evaluation of photoswitchable DFG-out RET kinase inhibitors
Abstract : Protein kinases are essential for signal transduction and regulate most cellular processes, such as metabolism, membrane transport, motility, and cell cycle. Although they play a critical role in cells and have a strong association with diseases, details of their physiologic and pathologic mechanisms remain at least partially unclear, especially the spatiotemporal dynamics of the signalling. READ MORE
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2. Computer-aided drug design approaches in developing anti-cancer inhibitors
Abstract : The thesis entitled “computer-aided drug design approaches in developing anti-cancer drug” is divided into a total of six chapters. In the first chapter, an overview of drug discovery and development are introduced. READ MORE