Search for dissertations about: "DNA Damage genetics"

Showing result 1 - 5 of 32 swedish dissertations containing the words DNA Damage genetics.

  2. 1. Replication Dynamics in the DNA Damage Response

    Author : Petra Groth; Thomas Helleday; Geroge Iliakis; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA replication; homologous recombination; DNA double strand-breaks; ionizing radiation; alkylating agents; NATURAL SCIENCES; NATURVETENSKAP; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Abstract : Faithful DNA replication is essential and the induction of replication stress may have profound effects on genomic integrity. This is demonstrated by the formation of DNA double strand breaks (DSBs), considered to be the most toxic DNA lesions, at stalled replication forks. READ MORE

  4. 2. Archaeological Genetics - Approaching Human History through DNA Analysis

    Author : Evangelia Daskalaki; Anders Götherström; Mattias Jakobsson; Walther Parson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ancient DNA; pyrosequencing; molecular genetics; aDNA; neolithization; evolutionary genetics; mtDNA; viking age; archaeological genetics; genetik; evolutionsgenetik; naturvetenskap; neolitisering; vikingatid; arkeologisk genetik; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Abstract : There are a variety of archaeological questions, which are difficult to assess by traditional archaeological methods. Similarly, there are genetic and population genetic questions about human evolution and migration that are difficult to assess by studying modern day genetic variation. READ MORE

  5. 3. Single DNA Molecule Analysis – New Tools for Medical Diagnosis

    Author : My Nyblom; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; optical DNA mapping; DNA damage; DNA; single-molecule analysis; fluorescence microscopy; antibiotic resistance; nanofluidics; genetics;

    Abstract : The DNA molecule, the blueprint of life, contains an enormous amount of information. The information is coded by the combination of four bases; adenine, cytosine, guanine, and thymine, that, together with the sugar-phosphate backbones, make up the DNA double helix. READ MORE

  6. 4. Mitotic aberrations in mammalian cells

    Author : Anna Renglin Lindh; Thomas Helleday; Micheline Kirsch-Volders; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; aneuploidy; mitotic aberrations; chemical effects; human cancer; DNA repair; Genetics; Genetik;

    Abstract : Almost all cancer cells are aneuploid showing the wrong chromosome number and often with structural aberrations. The degree of aneuploidy correlates with an increase of the severity of the disease and tumour cells with chromosomal instability are more prone to acquire resistance to chemotherapy than other cells. READ MORE

  7. 5. Homologous recombination at replication forks in mammalian cells

    Author : Cecilia Lundin; Thomas Helleday; Klaus Erixon; Keith W. Caldecott; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik;

    Abstract : Accumulating evidence indicates that homologous recombination plays an important role in mammalian cells, primarily in the reactivation of stalled replication forks. During a normal round of replication, stalling of the replication fork occurs frequently when a nick or a lesion, which cannot be by-passed, is encountered. READ MORE