Search for dissertations about: "DNA Topoisomerases"
Showing result 1 - 5 of 14 swedish dissertations containing the words DNA Topoisomerases.
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1. DNA topoisomerases and nucleosome dynamics in fission yeast
Abstract : The organization of DNA and associated proteins into chromatin allows for compaction and protection of large eukaryotic genomes. However, it also poses a challenge to fundamental cellular processes such as DNA replication, recombination, repair and transcription. READ MORE
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2. Biochemical studies of mitochondrial DNA maintenance and topology
Abstract : Mitochondria are crucial organelles in eukaryotic cells that produce the majority of adenosine trisphosphate used by cells as an energy currency to drive metabolic processes. Due to the endosymbiotic origin of mitochondria, they have their own genetic material, a small circular double-stranded molecule (mtDNA) of 16. READ MORE
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3. Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue
Abstract : The treatment of human brain tumour is challenging in part due to the blood brain barrier and in part due to the specific biology of brain tumours that confer resistance to chemotherapy. For instance, the 5 years survival rate for patients carrying intracranial glioblastoma multiforme has remained at 4-5 % for the last 30 years. READ MORE
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4. Chromatin remodeling and dna topology in transcription and genome stability
Abstract : Eukaryotic DNA is wrapped around histone proteins to form nucleosomes, the fundamental repeating unit of chromatin. DNA packaging into chromatin both solves and creates problems. It allows the centimeters, or even meters, of DNA that constitute a eukaryotic genome to fit inside a micrometer-scale cell nucleus. READ MORE
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5. The Smc5/6 complex : linking DNA replication with chromosome segregation
Abstract : In order to faithfully propagate the genetic material from one generation to the next, cells need to properly replicate and segregate their chromosomes. The three well-conserved eukaryotic Structural Maintenance of Chromosomes (SMC) protein complexes, cohesin, condensin and the Smc5/6 complex (Smc5/6) organize chromosomes to ensure that the daughter cells receive a full complement of chromosomes. READ MORE