Search for dissertations about: "DNA adducts"

Showing result 16 - 20 of 53 swedish dissertations containing the words DNA adducts.

  2. 16. ³²P-postlabelling analysis of DNA adducts in fish as a biomarker of genotoxic exposure

    Author : Gunilla Ericson; Tracy K Collier; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; zoologisk ekologi; Animal Ecology;

    Abstract : The 32P-postlabelling assay was used for analysis of hydrophobic DNA adducts in fish as a biomarker of genotoxic exposure. DNA adducts were analysed in perch (Perca fluviatilis) and northern pike (Esox lucius), two relatively stationary fish species which are common in Swedish freshwater systems and along the Baltic coast. READ MORE

  4. 17. Analysis of DNA adducts of some low molecular weight aldehydes : methods development and application in human biomonitoring

    Author : Jia-Long Fang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Malondialdehyde (MA), acetaldehyde (Aa) and methylglyoxal (MG) are ubiquitously present in the environment and endogenously formed in animals and humans. They have been shown to be genotoxic and to readily react with DNA to form DNA adducts under physiological conditions. READ MORE

  5. 18. Polycyclic aromatic hydrocarbons : DNA damage and cell signaling

    Author : Åse Mattsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oxidative stress is a threat to our wellbeing. The formation of reactive oxygen species may result in oxidative lesions in DNA and RNA. When challenging A549 cells with 18O-labeled hydrogen peroxide, we found that RNA was between 14-25 times more sensitive to [18O]-8-oxoGuo formation than [18O]-8-oxodGuo formation in DNA. READ MORE

  6. 19. DNA lesions and carcinogenicity from the urban air pollutants 2- and 3-nitrobenzanthrone

    Author : Eszter Nagy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : 3-nitrobenzanthrone; 2-nitrobenzanthrone; diesel exhaust; carcinogenicity; acute toxicity; DNA adducts; oxidative stress; intratracheal; ingestion;

    Abstract : In the early 1990's, Japanese doctors in urban areas discovered an increasing incidence of lung cancer among women, which was not attributed to a change in diet or smoking. This led to a growing investigation of urban air, and subsequently the discovery of 3-nitrobenzanthrone (3-NBA), a pollutant originating from diesel emissions. READ MORE

  7. 20. Binding of benzo(a)pyrene metabolites and derivatives to DNA : characterization using optical spectroscopy techniques

    Author : Ola Undeman; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : DNA with covalently bound benzo(a)pyrene (BP) derivatives was studied with fluorescence spectroscopy, fluorescence decay measurements, fluorescence quenching measurements, light absorption and linear dichroism of flow oriented samples. The modified DNA was prepared in three different ways: (1) by incubating calf thymus DNA with rat liver micromomes, necessary cofactors and benzo(a)pyrene or derivatives of benzo(a)pyrene, (2) by isolating DNA. READ MORE