Search for dissertations about: "DNA adducts"
Showing result 21 - 25 of 53 swedish dissertations containing the words DNA adducts.
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21. Cancer Risk Assessment of Glycidol : Evaluation of a Multiplicative Risk Model for Genotoxic Compounds
Abstract : Humans are exposed to chemical compounds in everyday life, both from the environment and from endogenous processes. Some compounds constitute a risk for cancer development. One such compound is glycidol, which is genotoxic and an animal carcinogen. It is the model compound of this work, partly due to its presence in food. READ MORE
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22. Biomonitoring of epichlorohydrin and some related compounds
Abstract : This thesis considers epichlorohydrin (ECH), an important industrial chemical, that has been shown to be a carcinogen in experimental animals. The aim of this work is to improve the scientific basis for risk estimation of ECH and to suggest a reliable biomonitoring method for exposure. READ MORE
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23. Carcinogenic polycyclic aromatic hydrocarbons : theoretical, molecular, in vitro and cellular characterization of biotransformation and DNA damage
Abstract : Polycyclic aromatic hydrocarbons (PAHs) are widespread mutagenic and carcinogenic environmental pollutants, which require metabolic activation to electrophilic intermediates and subsequent covalent binding to critical targets in DNA to elicit their biological activity. Bayand fjord-region diol epoxides (DEs) have been identified as the ultimate mutagenic and carcinogenic metabolites of PAHs. READ MORE
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24. Emerging roles of PFKFB3 and CX3CR1 in the DNA damage response and their potential as therapeutic targets in cancer
Abstract : Genomic instability in cancer is exploited therapeutically using DNA damaging therapies that cause irreparable lesions above the threshold of tolerable DNA damage levels. Nevertheless, toxic side effects on healthy tissues limit the therapeutic potential of such therapies. READ MORE
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25. Applications of Chromophores and Multiphoton Techniques to Study Structure and Interactions of Bio-macromolecules in Assembled State
Abstract : The research presented in this thesis is concerned with the linear and nonlinear optical properties of biopolymers and the chromophores that bind to them. This thesis combines analyses of the interactions of biomolecules with technological improvements of already existing systems for bionanotechnology-related research. READ MORE