Search for dissertations about: "DNA adducts"
Showing result 6 - 10 of 53 swedish dissertations containing the words DNA adducts.
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6. Studies on DNA adducts and carcinogenesis with 2-nitrofluorene as a model substance
Abstract : A number of carcinogens or their electrophilic intermediates are able to bind covalently to DNA, forming DNA adducts. DNA adducts may cause gene mutations if they are misrepaired or remain unrepaired before DNA replication occurs. DNA adduct formation is believed to be the initial step of chemical carcinogenesis. READ MORE
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7. 32P-postlabelling analysis of complex DNA adducts in human tissues
Abstract : Complex DNA adducts in humans originate from exogenous and endogenous sources. Polycyclic aromatic hydrocarbons (PAHs) are a large group of chemicals including many potent carcinogens. PAHs are ubiquitously present in the environment and PAH-DNA adducts have been extensively studied in humans. READ MORE
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8. DNA adducts as biomarkers of exposure to some dietary carcinogens
Abstract : Humans are exposed to many chemicals via intake of food and drink and there are strong associations between dietary factors and cancer. Exposure to the dietary carcinogens acrylamide and acetaldehyde are potential health risks that have made the headlines. High levels of acrylamide are found in various food items, such as potato chips. READ MORE
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9. Pharmacokinetic and pharmacodynamic studies on cisplatin in mice and men
Abstract : Methodological tools for studies of the cytostatic agen cisplatin (CDDP) were explored and applied to elucidate various aspects of pharmacokinetics, drug distribution, chemomodulation and pharmacodynamics. An immunohistochemical assay for analysis of CDDP-DNA adducts, i.e. READ MORE
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10. Chemometrics : Unravelling information from complex data generated by modern instruments
Abstract : Chemometrics is a discipline dedicated to solving problems arising from complicated analytical systems, combining statistics, mathematics, and computational programming languages.This thesis is based on the work developed in four scientific projects published as papers in scientific journals. READ MORE