Search for dissertations about: "DNA binding affinity"

Showing result 1 - 5 of 142 swedish dissertations containing the words DNA binding affinity.

  2. 1. Stability of bacterial DNA in relation to microbial detection in teeth

    Author : Malin Brundin; Ulf Sjögren; Anders Johansson; David Figdor; Inge Fristad; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-bound DNA; cell-death; dentine; DNA binding affinity; DNA decomposition; DNA preservation; extracellular DNA; hydroxyapatite; PCR; polymerase chain reaction; odontologi; Odontology;

    Abstract : The fate of DNA from dead cells is an important issue when interpreting results from root canal infections analysed by the PCR technique. DNA from dead bacterial cells is known to be detectable long time after cell death and its stability is dependent on many different factors. READ MORE

  4. 2. Statistical models of TF/DNA interaction

    Author : Aymeric Fouquier d'Herouel; Erik Aurell; Otto Berg; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; gene expression; regulation; transcription factor; binding motif; matrix representations; gibbs sampling; binding affinity; non-specific binding; Biological physics; Biologisk fysik;

    Abstract : Gene expression is regulated in response to metabolic necessities and environmental changes throughout the life of a cell. A major part of this regulation is governed at the level of transcription, deciding whether messengers to specific genes are produced or not. READ MORE

  5. 3. Structural and Functional Studies of Wilms Tumour Protein - WT1; Novel Insights into Functionality of Zinc Finger Proteins

    Author : Elmar Nurmemmedov; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Naturvetenskap; Natural science; function; structure; transcription factor; cancer; affinity; kinetics; Biacore; RNA binding; DNA binding; Wilms tumour WT1 ; zinc finger;

    Abstract : The molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. READ MORE

  6. 4. Chiral Ruthenium Dipyrodiphenazine Complexes: DNA Binding and Excited State Relaxation

    Author : Björn Önfelt; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; polarization spectroscopy; DNA-probe; dppz; excited-state relaxation; intercalation; solvent relaxation; DNA-threading;

    Abstract : Ruthenium complexes with aromatic ligands have been extensively studied due to their interesting photophysical properties, including photophysics and electron transfer upon interaction with nucleic acids. For example, the broad absorption spectrum makes them suitable as antenna molecules in photochemical reaction systems and their ability to accept or donate electrons in their excited state could have potential in opto-electronical devices. READ MORE

  7. 5. Development of Fluorescent Nucleobase Analogues - Intrinsically labelled nucleic acids for molecular binding investigations

    Author : Mattias Bood; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA; RNA; Fluorescent nucleobase analogue; FRET; pre-microRNA; isothermal titration calorimetry; surface plasmon resonance; aminoglycoside; binding interaction;

    Abstract : This thesis focuses on the design, synthesis and utilization of fluorescent nucleobase analogues (FBAs). FBAs are an important class of compounds, used in the research of nucleic acids. The class of canonical FBAs, i.e. READ MORE