Search for dissertations about: "DNA binding"

Showing result 11 - 15 of 828 swedish dissertations containing the words DNA binding.

  2. 11. Statistical models of TF/DNA interaction

    Author : Aymeric Fouquier d'Herouel; Erik Aurell; Otto Berg; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; gene expression; regulation; transcription factor; binding motif; matrix representations; gibbs sampling; binding affinity; non-specific binding; Biological physics; Biologisk fysik;

    Abstract : Gene expression is regulated in response to metabolic necessities and environmental changes throughout the life of a cell. A major part of this regulation is governed at the level of transcription, deciding whether messengers to specific genes are produced or not. READ MORE

  4. 12. NMR structral studies on ruthenium complexes binding to DNA

    Author : Lisha Wu; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMR; DNA binding; Ru-complex dimer; CD; fluorescence; molecular dynamics simulation;

    Abstract : The Ru-complex Λ,Λ-[bidppz(bipy)4Ru2]4+ (Λ,Λ-B) exhibits multiple modes of interactions with the palindromic DNA dodecamer [d(CGCGAATTCGCG)]2, however excluding any type of intercalation as shown by both optical spectroscopy and NMR. NMR observation of Λ,Λ-B titration into a DNA solution results in both a transient binding, with observation of fast exchange for protons located near the ends of the DNA duplex, and a more stable interaction in the DNA minor groove indicated by a slow exchange mechanism and binding sites for G2, G4 and A5 of the same DNA strand. READ MORE

  5. 13. Controlling DNA compaction and the interaction with model biomembranes

    Author : Marie-Louise Ainalem; Fysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; model biomembrane; DNA compaction; cryo-TEM; null ellipsometry; dynamic light scattering; toroid; bilayer; neutron reflectivity; dendrimer; PAMAM; DNA; poly amido amine ;

    Abstract : The studies described in this thesis forms part of a larger collaborative project, Neonuclei, with the objective to design a module for packaging the negatively charged DNA into a ”neonucleus” with transcription competence. There are many applications that require control of DNA compaction, i.e. packaging or condensation. READ MORE

  6. 14. Development of methods for optical mapping of nanoconfined DNA

    Author : Lena Nyberg; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; competitive binding; optical mapping; YOYO-1; nanofluidics; antibiotic resistance; fluorescence microscopy; single-molecule; DNA; plasmids; netropsin;

    Abstract : .... READ MORE

  7. 15. Structural Adaptation of DNA to Small Ligands and Recombination Proteins

    Author : Hye-Kyung Kim; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; triplex DNA; groove binders; intercalators; SANS; DNA; optical spectroscopy; recombination proteins;

    Abstract : In order to contribute to the understanding of mechanisms of recognition in nucleic acid systems, the interaction of DNA with a variety of ligands, representing different cases of adaptation of the double-helix structure, was studied using flow linear dichroism (LD), circular dichroism (CD), fluorescence and absorption spectroscopic techniques. A chiral hydrophobic metal complex, [Ru(dpphen)3]2+ was examined, since this had been reported to be the most efficient molecule to discriminate DNA handedness. READ MORE