Search for dissertations about: "DNA double-strand break"

Showing result 1 - 5 of 30 swedish dissertations containing the words DNA double-strand break.

  1. 1. DNA double-strand break repair in ascomycetes

    University dissertation from Stockholm : The Wenner-Gren Institute, Stockholm University

    Author : Jiang Chen; Stefan Åström; Michael Lisby; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; utvecklingsbiologi; Developmental Biology;

    Abstract : Nonhomologous end joining (NHEJ) and homologous recombination (HR) are two pathways for DNA double strand break (DSB) repair. We found that the NHEJ protein Nej1 interacted physically with the HR protein Srs2, which was dependent on phosphorylation of Nej1 by Dun1. Srs2 recruitment to a DSB partly relied on Nej1 and Dun1. READ MORE

  2. 2. Recognition and signaling of DNA double-strand breaks in human cells

    University dissertation from Stockholm : The Wenner-Gren Institute, Stockholm University

    Author : Ismail Hassan Ismail; Göteborgs universitet.; Gothenburg University.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA-PK; DNA double-strand break; DSB; DNA single-strand break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin kappa1; ATM; hydrogen peroxide; H2AX; radiotherapy; radiosensitizer; flow cytometry;

    Abstract : DNA double-strand breaks (DSBs) are the most toxic type of DNA damage. Fortunately, our cells have highly conserved pathways that detect and repair DSBs. Defects in DSB signaling and DSB repair pathways result in genomic instability that predisposes for cancer development. READ MORE

  3. 3. Characterization of Budding Yeast Nonhomologous End-Joining at DNA Double-Strand Breaks and Telomeres

    University dissertation from Stockholm : Wenner-Grens institut för experimentell biologi

    Author : Sidney Carter; Stefan Åström; Ed Louis; [2008]
    Keywords : DNA repair; nonhomologous end-joining; double-strand break; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : The yeast K. lactis efficiently integrates DNA by illegitimate recombination (IR). IR was completely dependent upon nonhomologous end-joining (NHEJ). In contrast to S. READ MORE

  4. 4. Measurements of the DNA double-strand break response

    University dissertation from Stockholm : Wenner-Grens institut för experimentell biologi

    Author : Aida Muslimovic; Göteborgs universitet.; Gothenburg University.; [2012]
    Keywords : DSB response; cancer patients; H2AX phosphorylation;

    Abstract : Radiotherapy and some chemotherapeutic drugs kill cancer cells by induction of the extremely toxic DNA double-strand breaks (DSBs). Measurements of the DSB response in patients during therapy could allow personalized dosing to improve tumor response and minimize side effects. READ MORE

  5. 5. Silencing and DNA double-strand break repair in budding yeast

    University dissertation from Stockholm : Wenner-Grens institut för experimentell biologi

    Author : Andreas Kegel; Stefan Åström; Stephan Marcand; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Silencing; Reb1; DSB; NHEJ; Nej1; illegitimate recombination; yeast; NATURAL SCIENCES Biology Organism biology Developmental biology; NATURVETENSKAP Biologi Organismbiologi Utvecklingsbiologi;

    Abstract : Transcriptional silencing that makes large chromosomal domains inaccessible for the transcriptional apparatus is nucleated at DNA elements called silencers. In K.lactis a 102bp HMLα silencer was defined revealing three distinct protein-binding regions (A, B, and C) that were required for silencing of HMLα. READ MORE