Search for dissertations about: "DNA double-strand break"

Showing result 16 - 20 of 33 swedish dissertations containing the words DNA double-strand break.

  2. 16. DNA fragmentation in cultured cells exposed to high linear energy transfer radiation

    Author : Erik Höglund; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Onkologi; Oncology; Onkologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Abstract : The DNA double-strand break (DSB) is a critical lesion which, if not completely restored, can have serious biological consequences. The relative biological effectiveness (RBE) of many severe end-points are closely related to radiation quality, with increased effectiveness at elevated ionization density. READ MORE

  4. 17. Involvement of Homologous Recombination in Response to Different Qualities of DNA Damage

    Author : Gunilla Olsson; Mats Harms-Ringdahl; John Thacker; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi;

    Abstract : The present studies aimed at elucidate the role of homologous recombination (HR) for the repair of different qualities of DNA damages and/or changes in chromatin structure induced by a variety of radiation qualities.Radiation qualities used to expose cells in culture ranged from non-ionizing radiation with extremely low frequency (ELF), of energies too low to disrupt chemical or molecular bonds, to radiation qualities with energies able to induce ionizations and break chemical bonds. READ MORE

  5. 18. DNA-dependent protein kinase in normal and malignant cells : with special reference to anti-tumour agent sensitivity

    Author : Åsa Holgersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA-PK; lymphoid maturation; lymphocytic leukaemia; radiation sensitivity; drug sensitivity; drug resistance; sensitisation.;

    Abstract : The DNA-dependent protein kinase (DNA-PK) is a DNA double strand break (DSB) repair enzyme, essential for the cellular response to DNA damaging agents. DNA-PK is also of importance for lymphoid development, since it includes two processes, V(D)J recombination and lg switch recombination, during which DSBs are naturally occurring events. READ MORE

  6. 19. Towards a cohesive understanding of the DNA damage response as a therapeutic target

    Author : Martin Scherzer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : At the basis of the complexity that forms a human being is a highly regulated interplay of factors found at a molecular, cellular, and macroscopic level. Ever since we evolved to work this way, even the slightest dysregulation at the molecular level can cascade and manifest as a non-communicable disease which ultimately affects the whole organism. READ MORE

  7. 20. Finding synergies for cancer treatment : new ways to modulate DNA damage repair by CX3CR1 and PFKFB3 inhibition

    Author : Jemina Lehto; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The goal of targeted cancer therapy is to selectively kill cancer cells based on their molecular survival mechanisms. DNA repair is as a promising cancer target as many cancers have chronic replication stress and deficiencies in the DNA damage response. READ MORE