Search for dissertations about: "DNA methylation in cancer"

Showing result 1 - 5 of 127 swedish dissertations containing the words DNA methylation in cancer.

  2. 1. Circulating markers of risk and etiology in colorectal cancer

    Author : Justin Harbs; Sophia Harlid; Bethany van Guelpen; Xijia Liu; Henrik Grönberg; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Colorectal cancer; CRC; sex hormones; colon cancer; DNA methylation; proteomics; risk; etiology; Cancer Epidemiology; cancerepidemiologi;

    Abstract : Background: Colorectal cancer is the third most commonly diagnosed cancer in men and women. Worldwide around 2 million individuals are diagnosed each year – a number expected to increase as colorectal cancer risk factors become more prevalent. READ MORE

  4. 2. DNA methylation signatures in precursor lymphoid neoplasms : with focus on clinical implications & the biology behind

    Author : Zahra Haider; Sofie Degerman; Magnus Hultdin; Göran Roos; Pieter van Vlierberghe; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Acute Lymphoblastic Leukemia; Lymphoma; T-ALL; BCP-ALL; T-LBL; DNA methylation; CIMP; Prognosis; TAL1; HOX.;

    Abstract : Precursor lymphoid neoplasms, namely acute lymphoblastic leukemias (ALL) and lymphoblastic lymphomas (LBL), are characterized by an aggressive proliferation of malignant progenitor B- or T-cells. To improve risk classification at diagnosis, better prognostic and treatment stratifying biomarkers are needed. READ MORE

  5. 3. Gene Expression and DNA Methylation in Acute Lymphoblastic Leukemia

    Author : Jessica Nordlund; Syvänen Ann-Christine; Xavier Estivill; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Digital gene expression; Allele-specific gene expression; DNA methylation; Epigenetics; Acute lymphoblastic leukemia; Molekylär medicin; Molecular Medicine;

    Abstract : Pediatric acute lymphoblastic leukemia (ALL) is the most common malignancy in children, which results from the malignant transformation of progenitor cells in the bone marrow into leukemic cells. The precise mechanisms for this transformation are not well defined, however recent studies suggest that aberrant regulation of gene expression or DNA methylation may play an important role. READ MORE

  6. 4. Biological signature of HER2-positive breast cancer

    Author : Breezy Malakkaran Lindqvist; Sten Wingren; Torbjörn Nilsson; Ingrid Hedenfalk; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HER2 breast cancer; SLC25A43; CpG island; DNA methylation; Homeobox genes; FOXO3a; FOXG1; Biomedicin; Biomedicine;

    Abstract : Human epidermal growth factor receptor 2 (HER2) overexpressing breast cancers (HER2+ breast cancer) are associated with an aggressive disease course. This thesis is focused on improving the understanding of the biological signature of HER2+ breast cancer. READ MORE

  7. 5. DNA methylation as a prognostic marker in clear cell Renal Cell Carcinoma

    Author : Emma Andersson-Evelönn; Sofie Degerman; Magnus Hultdin; Göran Roos; Börje Ljungberg; Ralph Peeker; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clear cell renal cell carcinoma; DNA methylation; Prognosis; Clinical outcome; Epigenetic classifiers;

    Abstract : Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cell carcinoma worldwide. Metastatic ccRCC is correlated to poor prognosis whereas non-metastatic disease has a 5-year survival rate up to 90%. READ MORE