Search for dissertations about: "DNA polymerase γ"

Found 3 swedish dissertations containing the words DNA polymerase γ.

  2. 1. The consequences of DNA lesions for mitochondrial DNA maintenance

    Author : Josefin M. E. Forslund; Sjoerd Wanrooij; Nasim Sabouri; Erik Johansson; Claes Gustafsson; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mitochondrial DNA; DNA replication; DNA lesions; DNA polymerase γ; ribonucleotide incorporation; medicinsk biokemi; Medical Biochemistry;

    Abstract : Eukaryotic cells have their own energy-producing organelles called mitochondria. The energy is stored in the adenosine triphosphate (ATP) molecule and is produced via the oxidative phosphorylation process inside the mitochondria. Thirteen of the essential proteins required for this process are encoded on the mitochondrial DNA (mtDNA). READ MORE

  4. 2. Mitochondrial DNA mutations. Brain developmental and ageing consequences, and possible treatments

    Author : Jaime M. Ross; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Ageing is a complex process that involves cellular senescence, a gradual loss of tissue homeostasis, and decline in organ function. Abundant evidence implicates mitochondria in ageing suggesting: (i) accumulation of mitochondrial DNA (mtDNA) damage, (ii) progressive respiratory chain dysfunction, and (iii) increased reactive oxygen species production. READ MORE

  5. 3. Signal transduction pathways leading to apoptosis or necrosis in insulin-producing cells and prevention of cell death using gene transfer

    Author : Johan Saldeen; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cells; apoptosis; Bcl-2; p38 mitogen activated kinase; NF-kB; necrosis; sphingomyelmase; ceramide; poly ADP-ribose polymerase; nitric oxide; IL-1β; TNF-a; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Signal transduction pathways potentially involved in destruction of insulin-producing β-cells in type-l diabetes and gene transfer to prevent β-cell death were studied in vitro. Adenovirus-polylysine/DNA complexes (AdpL) or polycationic liposomes mediated high reporter gene expression in dissociated primary human, fetal porcine, rat and mouse islet cells whereas gene transfer to intact islets was less efficient. READ MORE