Search for dissertations about: "DNA polymerase γ"

Found 5 swedish dissertations containing the words DNA polymerase γ.

  2. 1. The consequences of DNA lesions for mitochondrial DNA maintenance

    Author : Josefin M. E. Forslund; Sjoerd Wanrooij; Nasim Sabouri; Erik Johansson; Claes Gustafsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mitochondrial DNA; DNA replication; DNA lesions; DNA polymerase γ; ribonucleotide incorporation; medicinsk biokemi; Medical Biochemistry;

    Abstract : Eukaryotic cells have their own energy-producing organelles called mitochondria. The energy is stored in the adenosine triphosphate (ATP) molecule and is produced via the oxidative phosphorylation process inside the mitochondria. Thirteen of the essential proteins required for this process are encoded on the mitochondrial DNA (mtDNA). READ MORE

  4. 2. Molecular mechanisms of mitochondrial DNA replication

    Author : Teresa Holmlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Mitochondria; mtDNA; replication; helicase; TWINKLE; POLgamma; POLgammaB; mtSSB; adPEO;

    Abstract : Mitochondria are the energy producing organelles of eukaryotic cells. The organelle has its own genome, the mitochondrial DNA (mtDNA) that encodes 13 subunits of the respiratory chain (RC) complexes, two rRNAs and 22 tRNAs. READ MORE

  5. 3. Biochemical studies of mitochondrial DNA maintenance and topology

    Author : Direnis Erdinc; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mtDNA maintenance; topoisomerase; replication;

    Abstract : Mitochondria are crucial organelles in eukaryotic cells that produce the majority of adenosine trisphosphate used by cells as an energy currency to drive metabolic processes. Due to the endosymbiotic origin of mitochondria, they have their own genetic material, a small circular double-stranded molecule (mtDNA) of 16. READ MORE

  6. 4. Molecular and structural studies of proteins required for mitochondrial DNA maintenance

    Author : Carlos Pardo-Hernandez; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mtDNA; LONP1; POLγ; mtDNA maintenance; mitochondrial disease; TWINKLE; mitochondria;

    Abstract : Mitochondria are membrane-bound organelles that produce the majority of ATP used to drive metabolic processes in eukaryotic cells. A unique feature of mitochondria is the existence of a separate mitochondrial DNA (mtDNA), which codes for thirteen proteins needed for oxidative phosphorylation (OXPHOS). READ MORE

  7. 5. Mitochondrial DNA mutations : brain developmental and ageing consequences, and possible treatments

    Author : Jaime M Ross; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Ageing is a complex process that involves cellular senescence, a gradual loss of tissue homeostasis, and decline in organ function. Abundant evidence implicates mitochondria in ageing suggesting: (i) accumulation of mitochondrial DNA (mtDNA) damage, (ii) progressive respiratory chain dysfunction, and (iii) increased reactive oxygen species production. READ MORE