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Showing result 1 - 5 of 121 swedish dissertations matching the above criteria.

  2. 1. Fluorescence Probing of DNA Structures in Biology and Nanotechnology

    Author : Peter Sandin; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA; Fluorescent DNA base analog; UV‐Vis spectroscopy; DNA nanostructure; self‐assembly; time‐resolved fluorescence spectroscopy;

    Abstract : Much has been learnt about DNA since its structure was discovered about half a century ago. Scientists everlasting urge to look beyond and deeper into the intricate machinery of life, has continuously pushed technology forward. READ MORE

  4. 2. Digital Electrical DNA Sensing

    Author : Maoxiang Guo; Wouter van der Wijngaart; Fredrik Westerlund; KTH; []
    Keywords : DNA detection; thiol-ene-epoxy; rolling circle amplification; digital measurement; DNA stretching; microwell-array; gold nanowires; electrical measurement; specificity; limit of detection; liquid storage; disease diagnosis; lab-on-a-chip; point-of-care.;

    Abstract : Molecule detection is a workhorse in life sciences and medicine, for example in cancer diagnosis and virus and bacterial detection. DNA analysis can provide vital information about the state of a host organism and its medical and health condition. READ MORE

  5. 3. Mitochondrial DNA in Sensitive Forensic Analysis

    Author : Martina Nilsson; Marie Allen; Ulf Gyllensten; Antti Sajantila; Uppsala universitet; []
    Keywords : Genetics; Forensic genetics; Mitochondrial DNA; HVI HVII; Nuclear DNA; Quantification; Real-time PCR; Immobilised SSO probe assay; Pyrosequencing; Discrimination power; Coding region; Mixtures; Genetik;

    Abstract : Genetic profiling is commonly performed on the autosomes using multiple DNA markers. Although routine forensic DNA analysis is robust and based on reliable technologies, samples with degraded or limited amounts of DNA often fail. In these cases, the analysis of mitochondrial DNA (mtDNA) can be very valuable due to the high copy number per cell. READ MORE

  6. 4. Polarized light spectroscopy studies of model membranes and DNA

    Author : Maxim Kogan; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; emission; ruthenium dipyridophenazine complex; lipid bilayer; linear dichroism; membrane model; membrane orientation; bimolecular probe; DNA;

    Abstract : Over the past decades Linear Dichroism (LD) spectroscopy has proven to be a powerful tool for studies of structure and functioning of different cell constituents, including DNA, cell membranes and proteins. Due to structural complexity of cell constituents, the LD studies of biomolecules depend on development of simplified model systems, which can mimic the original structure and functionality of the cell components. READ MORE

  7. 5. Chiral Ruthenium Dipyrodiphenazine Complexes: DNA Binding and Excited State Relaxation

    Author : Björn Önfelt; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; polarization spectroscopy; DNA-probe; dppz; excited-state relaxation; intercalation; solvent relaxation; DNA-threading;

    Abstract : Ruthenium complexes with aromatic ligands have been extensively studied due to their interesting photophysical properties, including photophysics and electron transfer upon interaction with nucleic acids. For example, the broad absorption spectrum makes them suitable as antenna molecules in photochemical reaction systems and their ability to accept or donate electrons in their excited state could have potential in opto-electronical devices. READ MORE