Search for dissertations about: "DNA repair"
Showing result 11 - 15 of 333 swedish dissertations containing the words DNA repair.
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11. The role of chromatin in the induction and repair of DNA damage
Abstract : The role of chromatin in the induction and repair of DNA damage has a dual nature.The constituent proteins of chromatin protect the DNA against the induction of DNAdamage, while at the same time they reduce the accessibility of DNA to repair enzymes. READ MORE
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12. Chemically Induced DNA Damage in Extended-term Cultures of Human Lymphocytes
Abstract : Generation of DNA damage is regarded to be an important initial event in the development cancer. Consequently, a battery of tests have been developed to detect different types of genotoxic effects in order to be able to predict the potential genotoxicity and mutagenicity of chemicals, including both pharmaceutical drugs and various types of environmental and occupational agents, as well as dietary factors. READ MORE
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13. Repair of DNA double-stranded breaks in human cells
Abstract : DNA is continuously subjected to degradation. Therefore, our cells need to constantly repair its DNA to prevent mutations and in the long run cancer. In mammalian cells, when DNA is broken right off, a double-stranded break (DSB) is produced, and the ends are ligated by a process called non-homologous end-joining (NHEJ). READ MORE
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14. Interstrand Crosslinks - Induction and repair
Abstract : DNA crosslinking agents exhibit a variety of DNA lesions, such as monoadducts, DNA-DNA interstrand or intrastrand crosslinks or DNA-protein crosslinks. Agents that produce interstrand crosslinks (ICLs) exist naturally and are widely used in chemotherapy. Therefore, it is important to understand how the lesions induced by these agents are repaired. READ MORE
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15. Replication Dynamics in the DNA Damage Response
Abstract : Faithful DNA replication is essential and the induction of replication stress may have profound effects on genomic integrity. This is demonstrated by the formation of DNA double strand breaks (DSBs), considered to be the most toxic DNA lesions, at stalled replication forks. READ MORE