Search for dissertations about: "DNA synthesis"

Showing result 1 - 5 of 319 swedish dissertations containing the words DNA synthesis.

  1. 1. Structure of eukaryotic DNA polymerase epsilon and lesion bypass capability

    University dissertation from Umeå : Medicinsk kemi och biofysik

    Author : Nasim Sabouri; Erik Johansson; Lars Thelander; Ola Hammarsten; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA polymerase epsilon; DNA replication; Okazaki fragment; Translesion synthesis; DNA lesion; dNTP; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi;

    Abstract : To transfer the information in the genome from mother cell to daughter cell, the DNA replication must be carried out only once and with very high fidelity prior to every cell division. In yeast there are several different DNA polymerases involved in DNA replication and/or DNA repair. READ MORE

  2. 2. Fixation of Functionalized DNA Nanostructures

    University dissertation from Umeå : Medicinsk kemi och biofysik

    Author : Erik Lundberg; [2009]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; triplex recognition; dna; self-assembly; gel electrophoresis; nanotechnology; cross-linking; spectroscopy; fixation; fret; click chemistry;

    Abstract : This thesis features results from two different studies on a fully addressable non-repetitive network on the nanometre scale, assembled by synthetic DNA molecules. A bio-inspired molecular approach, based on principles of self-assembly, has brought about a paradigm shift in nanoscience, from a top-down to a bottom-up perspective. READ MORE

  3. 3. Role of yeast DNA polymerase epsilon during DNA replication

    University dissertation from Umeå : Medicinsk kemi och biofysik

    Author : Isabelle Isoz; Erik Johansson; Juhani Syväoja; [2008]
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; DNA polymerase epsilon; eukaryotic DNA replication; fidelity; leading strand; Dpb2; VETERINARY MEDICINE Biochemistry and clinical chemistry; VETERINÄRMEDICIN Biokemi och klinisk kemi;

    Abstract : Each cell division, the nuclear DNA must be replicated efficiently and with high accuracy to avoid mutations which can have an effect on cell function. There are three replicative DNA polymerases essential for the synthesis of DNA during replication in eukaryotic cells. READ MORE

  4. 4. Functional Cyclic Carbonate Monomers and Polycarbonates Synthesis and Biomaterials Applications

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jonas Mindemark; Tim Bowden; Andrew Dove; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA condensation; gene delivery; ionomers; polyplexes; self-assembly; amphiphiles; biodegradable; biological applications of polymers; transfection; cyclic carbonate monomers; polycarbonates; semicrystalline polymers; click chemistry; triazoles; cycloaddition; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Abstract : The present work describes a selection of strategies for the synthesis of functional aliphatic polycarbonates. Using an end-group functionalization strategy, a series of DNA-binding cationic poly(trimethylene carbonate)s was synthesized for application as vectors for non-viral gene delivery. READ MORE

  5. 5. Radiohalogenated Compounds for Tumor Targeting Synthesis and Radiolabeling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Eskender Mume; Stefan Sjöberg; Vladimir Tolmachev; D. Scott Wilbur; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Inorganic chemistry; 9-Aminoacridine; Daunorubicin; Doxorubicin; Carborane; Radiobromination; Radioiodination; Affibody; Monoclonal antibody; Oorganisk kemi; NATURAL SCIENCES Chemistry Inorganic chemistry; NATURVETENSKAP Kemi Oorganisk kemi;

    Abstract : This thesis describes the synthesis and radiohalogenation of compounds of potential use for tumor targeting.The first section describes the synthesis and radioiodination of DNA intercalating compounds. The compounds are derivatives of 9-aminoacridine, and the anthracyclins daunorubicin and doxorubicin. READ MORE