Search for dissertations about: "DNA uptake"
Showing result 11 - 15 of 129 swedish dissertations containing the words DNA uptake.
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11. Cell-penetrating peptides : Uptake mechanism and the role of receptors
Abstract : Genes are the major regulators of biological processes in every living thing. Problems with gene regulation can cause serious problems for the organism; for example, most cancers have some kind of genetic component. Regulation of biological processes using oligonucleotides can potentially be a therapy for any ailment, not just cancer. READ MORE
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12. Horizontal gene transfer by uptake of apoptotic bodies
Abstract : In adults as well as during embryogenesis, apoptosis plays a key role in the elimination of cells in multicellular organisms. Apoptosis is important for the maintenance of tissue homeostasis. It is also of importance in tumor development, where tumor cells die by apoptosis due to low levels of oxygen and nutrients. READ MORE
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13. Targeting double-stranded DNA with locked nucleic acid-based (LNA) oligonucleotides (ON) and DNA-binding peptide conjugates
Abstract : In this thesis we have studied two different types of molecules that bind to the major groove of the DNA: (i) oligonucleotides (ONs) containing locked nucleic acid (LNA) and in combination with intercalating agents (Twisted Intercalating Nucleic Acid, TINA, and Benzoquinoquinoxaline, BQQ) and (ii) peptides mimicking the leucine zipper transcription factor (GCN4 bZIP TF). Both ONs and peptides bind to the DNA double helix aiming to serve as transcription regulators of disease related genes. READ MORE
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14. Dendrimer-mediated gene delivery: Effect of polymer structure on cellular response
Abstract : The delivery of nucleic acids to cells, in vitro and in vivo, is becoming a realistic approach for intervention with gene expression at a molecular level. It can be used to repair malfunctioning genes or to introduce new functionalities, with the most important application being clinical treatment of human diseases. READ MORE
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15. Validation of Several Nucleoside Tracers as Proliferation Markers
Abstract : Positron emission tomography (PET) is a powerful method for in vivo characterization of tumor biochemistry and clinically has been used for diagnosing and grading of malignancy. A key element in oncology is proliferation potential, a feature that is assumed to be an important indicator of tumor growth. READ MORE