Search for dissertations about: "DNA vaccines"

Showing result 21 - 25 of 82 swedish dissertations containing the words DNA vaccines.

  2. 21. Development of vaccines and experimental models for chronic infections caused by the hepatitis C virus

    Author : Lars Frelin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HCV; chronic infection; DNA vaccine; NS3; viral vectors; transgenic mice;

    Abstract : The hepatitis C virus (HCV) is a major cause of chronic liver disease worldwide. It is estimated that HCV affects approximately 170 million people around the world. One feature of HCV infection is the high rate of viral persistence. READ MORE

  4. 22. Development of vaccines and mouse models for chronic hepatitis C virus infection

    Author : Sepideh Levander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic hepatitis C virus (HCV) infection is a major causative agent for severe liver disease and cancer worldwide. Globally, it is estimated that approximately 185 million people are infected with HCV and 130-170 million of these are chronic carriers of the virus (1, 2). READ MORE

  5. 23. Murine polyomavirus VP1 virus-like particles as vectors for gene therapy and as vaccines against polyomavirus infection and tumors

    Author : Andrea Vlastos Franzén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Polyomavirus; virus-like particles; pseudocapsids; gene therapy; vaccines; tumors;

    Abstract : Murine polyomavirus (MPyV) is a double stranded DNA virus ubiquitous in mice. The virus genome encodes for three transforming antigens that interact with the host cell machinery in order to initiate viral production. The transforming antigens can under certain circumstances when not controlled, e.g. READ MORE

  6. 24. Implications of Local Puumala Hantavirus Genetics and Epidemiology for Diagnostics and Vaccine Development

    Author : Patrik Johansson; Fredrik Elgh; Göran Bucht; Detlev Krüger; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; hantavirus; Puumala virus; nephropathia epidemica; genome sequence; glycosylation; linear DNA vaccine; microarray; identification; genetic variability; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar; medicinsk virologi; Medical Virology;

    Abstract : Puumala viruses, a member of the Hantavirus genus in the Bunyaviridae family, are enveloped by a lipid bilayer and possesses a tripartite single stranded RNA genome with negative polarity. The hantaviruses encode four proteins: a nucleocapsid protein (N), two membrane spanning glycoproteins (GN and GC) and a RNA dependent RNA polymerase (RdRp). READ MORE

  7. 25. Vaccine development strategies applied to the Plasmodium falciparum malaria antigen 332

    Author : Nina-Maria Vasconcelos; Klavs Berzins; Matti Sällberg; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; malaria; sub-unit vaccines; immunogenicity; antibody response; antigen Pf332; Immunology; Immunologi;

    Abstract : Malaria is one of the major infectious diseases in the world with regard to mortality and morbidity, and the development of a vaccine against the malaria parasite Plasmodium falciparum is considered of high priority. The aim of the work presented in this thesis was to develop and characterize recombinant vaccine constructs based on the P. READ MORE