Search for dissertations about: "DNA vehicles"

Showing result 6 - 10 of 15 swedish dissertations containing the words DNA vehicles.

  2. 6. Nucleic acid delivery : reports from the search of the magic bullet

    Author : Joana Viola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Gene therapy is regarded as one of the most promising therapeutic approaches, since it has the potential to treat disorders by correcting malformations at the nucleic acids level rather than proteins, as opposed to conventional medicine. However, for non-viral gene therapy to successfully fulfill the requirements associated to the “magic bullet” has proven difficult. READ MORE

  4. 7. Round window membrane and delivery of biologically active agents into the cochlea

    Author : Amanj Saber; Mats Ulfendahl; Lars Lundman; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Karolinska Institutet Department of Clinical Neoruscience; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Round window membrane; sodium hyaluronate; chitosan; local cochlear drug delivery and gene delivery; Oto-rhino-laryngologi; Oto-Rhino-Laryngology; Biology; Biologi; Round window membrane; sodium hyaluronate; chitosan; local cochlear drug delivery and gene delivery;

    Abstract : Establishing efficient methods for local administration of drugs to the inner ear has great clinical relevance for the management of inner ear disorders. However, the administration route remains a critical issue. READ MORE

  5. 8. Nucleic acid based therapeutic approaches

    Author : Joacim Elmén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nucleic acid therapy comprises several approaches based on nucleic acid as the active therapeutic component to treat human disease. Antisense and short interfering RNA (siRNA) are two gene-silencing techniques in this category. Based on nucleic acid sequence recognition both techniques inhibit gene expression. READ MORE

  6. 9. Nucleic acid in gene delivery and gene regulation

    Author : Pedro Moreno; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The concept of gene therapy, initially attributed to a technology that would allow the correction of inherited genetic disease, has evolved over the years. The realization of the immense technical hurdles to achieve genetic correction led to a broadening of the concept now including the transfer of genetic material whose expression will counteract, mitigate or revert a disease phenotype. READ MORE

  7. 10. Delivery of gene-regulating agents : internalization mechanisms and novel vectors

    Author : Per Lundin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The sequencing of the human genome was expected to generate a veritable explosion of therapeutics for regulation of gene function, either through modulation of gene expression or through the replacement of defect genes. However, nucleic acid-based pharmacological agents suffer from issues of low bioavailability and unfavorable pharmacokinetics, wherefore these prospects have not yet been realized. READ MORE