Search for dissertations about: "DNA-PK"

Showing result 16 - 20 of 20 swedish dissertations containing the word DNA-PK.

  2. 16. DNA damage affecting thyroidal iodide transport: an explanation to thyroid stunning

    Author : Madeleine Nordén; Göteborgs universitet; []
    Keywords : thyroid; radioiodide; thyroid stunning; NIS; cell cycle; genotoxic stress; DNA damage; H2AX; ATM;

    Abstract : 131I is widely used clinically in the treatment of Graves´ disease and differentiated thyroid cancer. However, cellular and molecular effects of 131I irradiation in relation to absorbed dose are poorly documented. READ MORE

  4. 17. Targeting MTHFD1 and MTHFD2 as cancer treatment

    Author : Petra Marttila; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : One-carbon (1C) metabolism provides building blocks for nucleotide synthesis and therefore plays a central role in DNA replication and repair. To sustain rapid proliferation, cancer cells often upregulate their 1C metabolism, including the enzymes MTHFD1 and MTHFD2, as a part of their metabolic rewiring. READ MORE

  5. 18. Mdm2 phosphorylations : characterization and applications

    Author : Maria Malmlöf; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer is a widespread disease. In spite of all research resulting in new improved therapies, there are still many tumors that cannot be cured. To oppose that, also a preventive research approach is important with goals such as decreasing the human exposure to carcinogens. READ MORE

  6. 19. Molecular factors relevant to the radiosensitivity of human tumours

    Author : Anya Polischouk; Karolinska Institutet; Karolinska Institutet; []
    Keywords : c-Ha-ras; c-myc; radiosensitivity; DNA double-strand break repair; DNA singlestrand repair;

    Abstract : Oncogenes, activated copies of normal cellular genes, are involved in carcinogenesis and have been suggested to be determinants of cellular radiosensitivity (RS). Mutations and gene rearrangement of c-Ha-RAS and c-MYC oncogenes were analysed in 70 biopsies and 51 blood samples from the same patients and compared with RS estimated by the clinical tumour response and by response to irradiation of tumour samples using subrenal capsule assay. READ MORE

  7. 20. Analysis and characterization of chemo- and radiation therapy sensitizing strategies in tumours with focus on effects of phenothiazines on DNA damage response signalling

    Author : Katarzyna Zielinska-Chomej; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer is, despite rapid progress in development of new targeted therapies, still mainly treated with surgery, chemotherapy and/or radiation therapy. The last two mentioned conventional therapies often meet general obstacles such as normal cell toxicity and tumour cell resistance. READ MORE