Search for dissertations about: "DNA-interaction"

Showing result 11 - 15 of 18 swedish dissertations containing the word DNA-interaction.

  2. 11. Thermodynamics of protein-DNA interactions

    Author : Thomas Lundbäck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA-protein interactions; molecular recognition; thermodynamics; specificity.dehydration; salt dependence.;

    Abstract : This thesis treats the molecular recognition between DNA-binding proteins and DNA and the way these interactions are affected by the surrounding water solution and dissolved solutes. The work involves studies on the thermodynamics of sequence specific DNA-binding of the human glucocorticoid receptor DNA-binding domain and the nonsequence specific DNA- binding of Sso7d from the archaeon Sulfolobus solfataricus. READ MORE

  4. 12. Mechanism of conditional repression of human osteocalcin gene activity by glucocorticoids

    Author : Thomas Meyer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : glucocorticoid receptor; osteocalcin; gene regulation; TATA box element;

    Abstract : Bone is one of the major target sites of steroid hormone action. Steroid hormones like cortisol, vitamin D and estradiol are responsible for principle events associated with bone formation and resorption. READ MORE

  5. 13. Deciphering the transcriptional regulation code in colorectal cancer genome

    Author : Jian Yan; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Colorectal cancer (CRC) is the third most common cancer type to threaten life for both men and women in the developed world. The molecular mechanism of CRC is very complicated and involves changes in different categories of biological processes, among which a large number of mutations affecting either coding sequence of transcription factors (TFs) or their binding sites in genome are included. READ MORE

  6. 14. A holistic view on transcriptional regulatory networks in S. cerevisiae: Implications and utilization

    Author : David Bergenholm; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Transcription factors; S. cerevisiae; chemostat; transcriptomics; regulatory networks;

    Abstract : Life; perhaps it is bold to start an abstract with this powerful word, but this is where I will start. My research is at the heart of life. READ MORE

  7. 15. Nucleosome positioning : impact on transcription factors access

    Author : Qiao Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : glucocorticoid receptor; transcription factor; gene regulation; nucleosome; nucleosome positioning; DNA-bending sequence;

    Abstract : In the eukaryotic cell nucleus, DNA is organized into nucleosomes. Some of the regulatory regions are integrated into sequence-specifically positioned nucleosomes. READ MORE