Search for dissertations about: "DNA-protein interactions"

Showing result 1 - 5 of 14 swedish dissertations containing the words DNA-protein interactions.

  2. 1. DNA-protein complexes : experimental studies of structure and interactions in solution

    Author : Per Hagmar; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA binding domain; methylene blue; flow linear dichroism; recombination protein A; RecA; chromatin structure; recombination; electric linear dichroism; chromatin; glucocorticoid receptor;

    Abstract : .... READ MORE

  4. 2. Intelligent Nucleic Acid Interactions with Peptide Nucleic Acid (PNA) and Recombination Enzyme RecA

    Author : Pernilla Wittung; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; fluorescence; RecA; homologous recombination; circular dichroism; DNA analogs; -anti-BPDE; spectroscopy; PNA; DNA-protein interactions;

    Abstract : The work presented in this thesis focuses on interactions between nucleic-acids in biological systems, particularly interactions of the promising drug-candidate peptide nucleic acid (PNA), and on protein-DNA intermediates during recombination. Several experimental techniques, mainly circular dichroism and fluorescence spectroscopy, have been used to characterize the interactions of interest. READ MORE

  5. 3. The Epigenetics of Gene Transcription and Higher Order Chromatin Conformation

    Author : Vijay Kumar Tiwari; Rolf Ohlsson; Terumi Kohwi-Shigematsu; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; DNA-protein interactions; Nuclear organization; Transcriptional regulation; Higher order chromatin conformations; Epigenetic reprogramming; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Abstract : It is becoming increasingly clear that long-range control of gene expression is mediated through direct physical interactions between genes and regulatory elements, either intra- or interchromosomally. In addition to transcriptional initiation, formation of active chromatin hubs seem to be crucial for increased transcriptional efficiency as well as insulation from neighbouring heterochromatic environment. READ MORE

  6. 4. Nanofluidics for Static and Dynamic DNA-Protein Interaction Studies - Repair of Double-Strand Breaks from a Single-Molecule Perspective

    Author : Robin Öz; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Single-molecule; Protein; NHEJ; Dynamic; DNA repair; HR; Biomolecule interactions; Microscopy; Fluorescence; Nanofluidics;

    Abstract : Double-strand breaks (DSBs) is one of the most lethal forms of DNA damage. A single DSB may result in stalling of vital cellular machineries, and thus, requires immediate measures by the cell. READ MORE

  7. 5. Thermodynamics of protein-DNA interactions

    Author : Thomas Lundbäck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA-protein interactions; molecular recognition; thermodynamics; specificity.dehydration; salt dependence.;

    Abstract : This thesis treats the molecular recognition between DNA-binding proteins and DNA and the way these interactions are affected by the surrounding water solution and dissolved solutes. The work involves studies on the thermodynamics of sequence specific DNA-binding of the human glucocorticoid receptor DNA-binding domain and the nonsequence specific DNA- binding of Sso7d from the archaeon Sulfolobus solfataricus. READ MORE