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Showing result 1 - 5 of 12 swedish dissertations matching the above criteria.
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1. Immune modulation in serous epithelial ovarian cancer : focus on the role of tumor-derived exosomes
Abstract : Serous epithelial ovarian cancer (EOC) is a potent suppressor of the immune defense. Here, we studied interactions between EOC and the immune system that lead to escape from tumor immune surveillance. READ MORE
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2. Mechanisms for immune escape in epithelial ovarian cancer
Abstract : Tumors develop mechanisms to subvert the immune system, constituting immune escape. Epithelial ovarian cancer (EOC), the deadliest of all gynecological malignancies, uses a variety of mechanisms to undermine immune surveillance, aiding its establishment and metastatic spreading. READ MORE
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3. NK cell education and adhesion molecules : implications for immunotherapy
Abstract : NK cells have a key role in immune surveillance. They detect aberrant expression of stressinduced molecules and MHC class I molecules with an array of activating and inhibitory receptors. READ MORE
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4. Molecular specificities of NK cell-mediated recognition of human tumor cells
Abstract : Natural killer (NK) cells have been implicated in tumor immune surveillance and can reject transformed cells expressing ligands for activating NK cell receptors and low levels of HLA class I. Although NK cells are well known for their ability to kill tumor cells, relatively few studies have addressed the molecular specificity of NK cell-mediated recognition of freshly isolated human tumor cells. READ MORE
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5. Mechanisms influencing natural killer cell recognition of tumour cells
Abstract : Natural killer (NK) cells are part of our innate immune defence against virus-infected and transformed cells. Through a yet undefined mechanism, expression of inhibitory receptors for self-HLA class I molecules endow NK cells with increased functionality. The process leading to gain of function through inhibition is known as NK cell education. READ MORE