Search for dissertations about: "DNT"

Showing result 1 - 5 of 11 swedish dissertations containing the word DNT.

  2. 1. In search of a biosensor for DNT detection : Studies of inducer response and specificity of DntR

    Author : Rosa Lönneborg; Peter Brzezinski; Ray Dixon; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DntR; transcriptional regulation; gfp; nitro-aromatic compounds; LysR family; LTTR; TNT; DNT; FACS; directed evolution; random mutagenesis; recombination; structure determination; biokemi; Biochemistry;

    Abstract : The primary aim of the work presented in this thesis was to change the inducer specificity of the DntR protein in order to improve the response to DNT. The long-term goal is to use this protein in a biosensor for DNT, a signature compound for detection of the explosive TNT. READ MORE

  4. 2. Novel Endpoints To Unravel Developmental Neurotoxicity : From DNA methylation responses to methylmercury to the in vitro identification of endocrine disruptors

    Author : Andrea Cediel-Ulloa; Joëlle Rüegg; Pamela J. Lein; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Developmental neurotoxicity; Methylmercury; DNA methylation; Endocrine disruptors; in vitro assay development; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Abstract : The developing brain is especially sensitive to environmental stressors due to its dependence on the precise spatiotemporal regulation of multiple signals, and the long time period required for its formation. Some chemicals can interfere with molecular and cellular processes driving brain development, including epigenetic processes such as DNA methylation. READ MORE

  5. 3. Data-Centric Network of Things : A Method for Exploiting the Massive Amount of Heterogeneous Data of Internet of Things in Support of Services

    Author : Bin Xiao; Rahim Rahmani; Theo Kanter; Mika Ylianttila; Stockholms universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Internet of Things; Big Data; Artificial Intelligence; Data Supply; Distributed System; Computer and Systems Sciences; data- och systemvetenskap;

    Abstract : Internet of things (IoT) generates massive amount of heterogeneous data, which should be efficiently utilized to support services in different domains. Specifically, data need to be supplied to services by understanding the needs of services and by understanding the environment changes, so that necessary data can be provided efficiently but without overfeeding. READ MORE

  6. 4. Developmental Neurotoxicity Testing Using In vitro Approaches

    Author : Helena Högberg; Anna Price; Barbara Cannon; Kevin Crofton; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologi; Toxicology;

    Abstract : There is a great concern about children’s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. READ MORE

  7. 5. Neurodevelopmental Consequences of Exposure to Paracetamol (Acetaminophen) and Related Drugs : Experimental studies in mice

    Author : Gaëtan Philippot; Robert Fredriksson; Vesna Jevtovic-Todorovic; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; paracetamol acetaminophen ; developmental neurotoxicology; delta9-tetrahydrocannabinol THC ; ibuprofen; endocannabinoid system; neonatal mice; brain growth spurt; behavior; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Abstract : Paracetamol (acetaminophen) is the analgesic pharmaceutical most commonly used during pregnancy and early life. While therapeutic doses of paracetamol are considered harmless during these periods, recent findings in both humans and rodents suggest a link between developmental exposure to paracetamol and behavioral consequences later in life. READ MORE