Search for dissertations about: "DOTA"

Showing result 1 - 5 of 25 swedish dissertations containing the word DOTA.

2. 1. Development of 18F- and 68Ga-Labelled Tracers : Design Perspectives and the Search for Faster Synthesis

   Author : Elisabeth Blom; Bengt Långström; Oleksiy Itsenko; Irina Velikyan; Farhad Karimi; Frank Rösch; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; PET; nucleophilic 18F-fluorination; perfluoro; F-SPE; molecular design; 68Ga; chelators; DOTA; NOTA; microwave; halogen exchange; harmine; biotin; RGD; VEGF; CRP; Chemistry; Kemi; Organisk kemi; Organic Chemistry;

   Abstract : This thesis deals with the design of 18F- and 68Ga-labelled positron emission tomography (PET) tracers and the development of technologies that enable faster and simpler preparation with high specific radioactivity. Techniques like microwave heating and reducing the concentrations of the precursor were investigated with this perspective. READ MORE

4. 2. 177Lu-DOTA-octreotate Radionuclide Therapy of Neuroendocrine Tumours : Dosimetry-Based Therapy Planning and Outcome

   Author : Ulrike Garske-Román; Barbro Eriksson; Anders Sundin; Jens Sörensen; Dik Kwekkeboom; Uppsala universitet; []
   Keywords : ;

   Abstract : Peptide receptor radionuclide therapy for the internal radiation of neuroendocrine tumours expressing somatostatin receptors has made great advances and offers promising results. 177Lu-DOTA-octreotate is one of the most widely used radiopeptides, but kidneys and bone marrow are organs at risk. READ MORE

5. 3. The Importance of Dosimetry and Radiobiology in Nuclear Medicine : Quantitative methods and modelling

   Author : Anna Stenvall; Lund Medicinsk strålningsfysik; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nuclear medicine; radionuclide therapy; radiopharmaceutical therapy; dosimetry; Monte Carlo modelling; radiobiology; ; γH2AX; DOTA-TATE; PET; SPECT;

   Abstract : Nuclear medicine uses radioactive pharmaceuticals for diagnostic or therapeutic purposes. The ionizing radiation emitted from the radiopharmaceutical is partially absorbed within the patient's body and internal dosimetry is the method to estimate the absorbed dose to a tumour or risk organ. READ MORE

6. 4. Computational and experimental methods for imaging and dosimetry in 177Lu radionuclide therapy : Classical and novel gamma cameras

   Author : Daniel Roth; Lund Medicinsk strålningsfysik; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Radionuklidterapi; [177Lu]Lu-DOTA-TATE; Gammakamera; Aktivitetskvantifiering; Dosimetri; CdZnTe; Monte Carlo; Radionuclide therapy; [177Lu]Lu-DOTA-TATE; Gamma camera imaging; Activity quantification; Dosimetry; CdZnTe; Monte Carlo;

   Abstract : Radionuclide therapy (RNT) is a form of radiotherapy that uses unsealed radioactive sources for the delivery of ionising radiation within a patient's body.Radiation dosimetry is not used routinely in all centres, and the RNT field can benefit from more data on pharmacokinetics and absorbed doses (ADs). READ MORE

7. 5. Translational PET imaging of inflammation

   Author : Emmi Puuvuori; Olof Eriksson; Tove Grönroos; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET imaging; Nuclear Medicine; Inflammation; Translational Medicine;

   Abstract : Inflammation is our body’s sophisticated defense mechanism against invading pathogens, traumas, and tumors. Repeatable and non-invasive monitoring of inflammation process would open opportunities to improve our knowledge of several diseases and enable assessment of personalized treatments. READ MORE