Search for dissertations about: "DRB1"

Showing result 11 - 15 of 88 swedish dissertations containing the word DRB1.

  2. 11. Genetic studies of the HLA locus in rheumatic diseases

    Author : Emeli Lundström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share a complex etiology consisting of both genetic and environmental components. Stimulation of lymphocytes and various other immune cells, release of cytokines, activation of complement and production of autoantibodies due to loss of tolerance to self-antigens, contributes to the pathogenesis of both RA and SLE. READ MORE

  4. 12. Genetic predispositions to rheumatoid arthritis in Malaysian population

    Author : Chun Lai Too; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Genetic predisposition is a significant and fundamental determinant of susceptibility to rheumatoid arthritis (RA), a complex autoimmune disease with a painful and disabling condition. The vast majority of genetic studies in RA have been centered on populations of European descent with very few studies on East Asian populations. READ MORE

  5. 13. Specific autoimmunity in rheumatoid arthritis : T cells, antibodies and genetic regulation

    Author : Omri Snir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Complex interactions between genes and environmental factors may result in destruction of the body’s own cells and tissues by the immune system, i.e. autoimmunity. Rheumatoid arthritis (RA) is a chronic joint inflammation mediated by all arms of the immune system that can lead to tissue destruction and functional disabilities. READ MORE

  6. 14. Conquering complexity : successful strategies for finding disease genes in multiple sclerosis

    Author : Kerstin Imrell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) is a complex disease; at an intra-individual level several contributory factors cause the disease; at an inter-individual level different factors contribute to the disease. The aim of the thesis project was to reduce this complexity by focusing of subsets of patients that were likely to share to a higher extent contributory causes and to identify in these subsets genes conferring susceptibility. READ MORE

  7. 15. Common viruses and host gene interactions in multiple sclerosis

    Author : Emilie Sundqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) is a neurological disorder, characterised by demyelination and inflammation of the central nervous system, leading to sensory and motor symptoms. MS is thought to be complex disease, with both environmental and genetic risk factors underlying disease susceptibility. READ MORE