Search for dissertations about: "DRUG POLYMORPHISM"
Showing result 1 - 5 of 81 swedish dissertations containing the words DRUG POLYMORPHISM.
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1. In vitro and in silico prediction of drug-drug interactions with transport proteins
Abstract : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. READ MORE
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2. Investigating polymorphism in small molecules using three-dimensional electron diffraction
Abstract : For scientific, regulatory and intellectual property reasons, the discovery and characterisation of polymorphic systems is an integral aspect of the development process of any solid-formulated drug product. Yet, these studies are often hindered by crystal quality and size, poor yields and the generation of mixtures of phases. READ MORE
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3. Cytochrome P450 2C9 polymorphism : interindividual differences in drug metabolism and phenotyping methodology
Abstract : Cytochrome P450 2C9 (CYP2C9) is one of the most important drug metabolizing enzymes in human liver. It catalyses the metabolism of a wide range of different drugs such as S-warfarin, acenocoumarol, losartan, irbesartan, phenytoin, sulphamethoxazole, tolbutamide, glipizide and numerous non-steroidal antiinflammatory drugs. READ MORE
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4. Inflammatory Response in Peripheral Arterial Disease
Abstract : Peripheral arterial disease (PAD) is the manifestation of atherosclerotic lesions in arteries supplying blood to the legs. Atherosclerosis is now recognized as an inflammatory disease of the vessel wall and important features in the pathophysiology are activation of WBC, endothelial cells and increased levels of inflammatory mediators. READ MORE
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5. Osteoporosis in elderly women; Bone traits, fracture and the PTH gene complex
Abstract : Background: Fragility fractures are a major health problem world wide and the numbers are growing due to ageing populations. Early identification of individuals at risk for osteoporosis and fracture, enabling preventive measures and treatment is essential. READ MORE