Search for dissertations about: "DUB"

Showing result 1 - 5 of 13 swedish dissertations containing the word DUB.

2. 1. Modulation of PDGF receptors function by posttranslational modifications

   Author : Kehuan Wang; Carl-Henrik Heldin; Johan Lennartsson; Natalia Papadopoulos; Jean-Baptiste Demoulin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signaling; receptor tyrosine kinase; ubiquitination; DUB; STAT3; SUMO; SUMOylation; cleavage; autophagy; SQSTM1 p62; LC3; GABARAP; bafilomycin A1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. READ MORE

4. 2. Potential New Drugs in Lymphoma

   Author : Maryam Delforoush; Gunilla Enblad; Mattias Berglund; Christina Drott; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphoma; diffuse large B-cell lymphoma; DLBCL; picropodophyllin; PPP; J1; melflufen; prodrug; cancer therapeutics; alkylating agents; b-AP15; proteasome inhibitors; DUB inhibition; UCHL5; USP14;

   Abstract : Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). READ MORE

5. 3. Modulation of the deubiquitinating system in viral infection, lymphoid cell activation and malignant transformation

   Author : Ulrika Rolén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Most cellular proteins are affected by the conjugation of Ubiquitin (Ub), which may regulate their stability, activity or localization. The family of deubiquitinating enzymes (DUBs) removes Ub from conjugates and regulates the production and recycling of Ub. READ MORE

6. 4. A Passage to Organization

   Author : Mikael Holmgren Caicedo; Birgitta Olsson; Alexander Styhre; Stockholms universitet; []
   Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; concatenation; instantiation; metaphor; metonymy; mimêsis; mûthos; organization; organizing; poetics; rhetoric; representation; Business studies; Företagsekonomi;

   Abstract : How does action turn [into a] substantive and, if it does, how does it turn into action again to perdure or even change?In this endeavor I set out to study organizing and organization by asking myself how organizing becomes a product called organization and how that product turns into the very organizing whence it once was spawned. In other words, I set out to study what I denominate the movements between organizing and organization. READ MORE

7. 5. Inhibition of 19S proteasome deubiquitinases as a promising strategy in cancer therapy

   Author : Magdalena Mazurkiewicz; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The ubiquitin proteasome system (UPS) is the main degradation system in the eukaryotic cell and it is involved in the regulation of many crucial cellular pathways; such as signal transduction, proliferation, DNA repair, cell death, and cell cycle regulation. In comparison to cells in healthy tissues, cancer cells proliferate faster and have increased protein synthesis rate; therefore in order to preserve cellular fitness they are more dependent on UPS than normal cells. READ MORE