Search for dissertations about: "DXR"

Showing result 11 - 14 of 14 swedish dissertations containing the word DXR.

  2. 11. Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia

    Author : Edward Laane; Karolinska Institutet; Karolinska Institutet; []
    Keywords : acute leukemia; glucocorticoids; doxorubicin; apoptosis; autophagy; minimal residual disease; dendritic cells;

    Abstract : Acute leukemia (AL) is a fatal disease, which causes rapid death in the absence of appropriate chemotherapeutic intervention. Long-term survival rates vary from 80% in childhood lymphoblastic AL (ALL) to 10-20% in adult myeloid AL (AML). READ MORE

  4. 12. Experimental studies on xenograft rejection

    Author : Guosheng Wu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The use of animal organs and tissues may provide a solution to the severe and worsening shortage of human grafts. The aims of the present experimental studies were to provide a better understanding of the rejection mechanisms and give new clues for prevention of xenorejection, thereby hopefully contributing to the development of clinical xenotransplantation. READ MORE

  5. 13. Computational Modelling in Drug Discovery : Application of Structure-Based Drug Design, Conformal Prediction and Evaluation of Virtual Screening

    Author : Martin Lindh; Anders Karlén; Antti Poso; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug discovery; docking; virtual screening; tuberculosis; conformal prediction;

    Abstract : Structure-based drug design and virtual screening are areas of computational medicinal chemistry that use 3D models of target proteins. It is important to develop better methods in this field with the aim of increasing the speed and quality of early stage drug discovery. READ MORE

  6. 14. Clinical and tumour biology studies of Diffuse Large B-cell Lymphoma : with emphasis on comorbidity, toxicity and outcome

    Author : Charlott Mörth; Gunilla Enblad; Kristina Drott; Uppsala universitet; []
    Keywords : DLBCL; autoimmune disease; cardiac toxicity; neurotoxicity; EFS; OS; Medicinsk vetenskap; Medical Science;

    Abstract : Diffuse large B-cell lymphoma (DLBCL) is curable in around 70% when treated with standard immunochemotherapy R- CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone). Treatment related toxicity affecting survivors is a clinical problem as well as comorbidities influencing the possibility to give adequate treatment. READ MORE