Search for dissertations about: "Dag Leonard"
Found 3 swedish dissertations containing the words Dag Leonard.
-
1. Cardiovascular Disease and Immune Mechanisms in Systemic Lupus Erythematosus
Abstract : Systemic lupus erythematosus (SLE) is an autoimmune, inflammatory disease characterized by autoantibody production and an activated type I interferon system. Cardiovascular disease (CVD) is as a major cause of morbidity and mortality. The aim of this thesis was to identify genetic risk factors for CVD in SLE. READ MORE
-
2. Genetic Contributions to Manifestations and Prognosis of Systemic Lupus Erythematosus
Abstract : Systemic lupus erythematosus (SLE) is a severe autoimmune disease with a multifactorial aetiology and an extremely heterogenous clinical picture. This thesis explores the impact of SLE genetic variants, through their cumulative effect or gene-environment interactions, on SLE manifestations and complications. READ MORE
-
3. Calcium and Phospholipases in Orexin Receptor Signaling
Abstract : The neuropeptides orexin-A and -B act as endogenous ligands for G-protein-coupled receptors (GPCRs) called OX1 and OX2 receptors. Previous observations have established that orexin receptors have an ability to couple to different G-proteins and signaling pathways and induce Ca2+ elevations via both receptor-operated Ca2+ channels (ROCs) and store-operated Ca2+ channels (SOCs). READ MORE