Search for dissertations about: "Danica Stanimirovic"

Found 2 swedish dissertations containing the words Danica Stanimirovic.

  2. 1. Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease

    Author : Sofia Gustafsson; Margareta Hammarlund-Udenaes; Stina Syvänen; Irena Loryan; Danica Stanimirovic; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Neurovascular unit; Pharmacokinetics; Neurodegenerative disease; Drug transport; Brain tissue binding; Positron emission tomography; Brain regions; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : A high unmet medical need in the area of CNS diseases coincides with high failure rates in CNS drug development. Efficient treatment of CNS disease is constrained by limited entrance of drugs into the brain owing to the blood-brain barrier (BBB), which separates brain from blood. READ MORE

  4. 2. Brain distribution of a bispecific antibody targeting Aβ

    Author : Gustavsson Tobias; Dag Sehlin; Stina Syvänen; Paul O'Callaghan; Danica Stanimirovic; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; blood-brain barrier; single-photon emission computed tomography SPECT ; bispecific antibody; immunotherapy; Molekylär medicin; Molecular Medicine; Neuroscience; Neurovetenskap;

    Abstract : Alzheimer’s disease (AD) is characterised by aberrant protein aggregation in the brain with subsequent synaptic loss, neuroinflammation, and brain atrophy that ultimately clinically manifests as cognitive impairment. Histopathological findings in AD are extracellular plaques of the protein amyloid-beta (Aβ), Aβ in blood vessels (CAA), and intracellular neurofibrillary tangles (NFT) of hyperphosphorylated tau. READ MORE