Search for dissertations about: "Dario Neri"

Found 4 swedish dissertations containing the words Dario Neri.

  2. 1. A Chemical Approach Toward the Therapeutic Optimization of Cytotoxic Bioconjugates

    Author : Rafael Hartmann; Luke R. Odell; Fredrik Lehmann; Mats Larhed; Dario Neri; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemotherapy; antibody-drug conjugates; organic synthesis; bioorganic chemistry; synthetic method development; analytical method development; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi; Medicinal Chemistry; Läkemedelskemi; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Abstract : The delivery of cytotoxicity to specific cells was recognized to be the key to the effective, chemical treatment of infectious and neoplastic diseases well over a century ago. In the context of oncology, the primary therapeutic challenge is the distinction between healthy and pathological cells despite their pronounced pheno- and genotypic similarity. READ MORE

  4. 2. Affibody Molecules Targeting VEGFR2 - Two Turns Off and Four Turns On

    Author : Rezan Güler; John Löfblom; Stefan Ståhl; Dario Neri; KTH; []
    Keywords : Protein engineering; affibody molecules; VEGFR2; angiogenesis; Bioteknologi; Biotechnology;

    Abstract : The notion of employing proteins as drugs traces back several decades. As recombinant DNA technology emerged, it became a powerful tool for the tailoring of protein traits via genetic approaches - so-called protein engineering. READ MORE

  5. 3. PNA and affinity protein tools for selective tumor targeting of radiopharmaceuticals

    Author : Hanna Tano; Amelie Eriksson Karlström; Per-Åke Nygren; Dario Neri; KTH; []
    Keywords : Cancer therapy; targeted radionuclide therapy; affinity proteins; Affibody molecules; CD38; GRPR; HER2; nanobody; peptide; PNA; RM26; pretargeting; Cancerterapi; radionuklid terapi; affinitetsproteiner; affibody molekyler; CD38; GRPR; HER2; nanobody; peptid; PNA; RM26; pretargeting; Biotechnology; Bioteknologi;

    Abstract : Targeted radiotherapy of cancer intends to selectively deliver cytotoxic radionuclides to tumor cells. Affinity proteins of various kinds are explored for this task, and depending on the affinity protein used, different challenges arise. READ MORE

  6. 4. Design and Evaluation of Radiolabeled Affibody Tracers for Imaging of HER2-expressing Tumors

    Author : Helena Wållberg; Stefan Ståhl; Dario Neri; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; radionuclide molecular imaging; HER2; radiotracer; SPECT; PET; biodistribution; protein engineering; radiolabeling;

    Abstract : The growing understanding of tumor biology and the identification of tumor specificgenetic and molecular alterations, such as the overexpression of human epidermal growthfactor receptor 2 (HER2), opens up for personalization of patient management using targeted therapies. However, this puts stringent demands on the diagnostic tools usedto identify patients that are likely to respond to a particular treatment. READ MORE