Search for dissertations about: "Debio 025"

Found 2 swedish dissertations containing the words Debio 025.

  2. 1. Calcium-induced mitochondrial permeability transition in CNS-derived mitochondria - Pharmacological aspects of specificity and toxicity in neuroprotection

    Author : Roland Månsson; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; mitochondria; brain; calcium; respiration; cell death; permeability transition; calcium retention; minocycline; neuroprotection; Debio 025;

    Abstract : Mitochondria are the main site for energy conversion in the cell. Under certain circumstances, such as excess calcium retention or production of reactive oxygen species, a pore forms at contact sites between the outer and the normally impermeable inner mitochondrial membrane. READ MORE

  4. 2. Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target

    Author : Magnus Hansson; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; farmakognosi; farmaci; Bioenergetik; Bioenergetics; neuropsykologi; toxikologi; neurofysiologi; Neurologi; Neurology; neurophysiology; neuropsychology; Neurodegeneration; Mitochondria; Brain; Pharmacological sciences; pharmacognosy; pharmacy; Farmakologi; toxicology;

    Abstract : There is currently no clinically available drug with neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. READ MORE