Search for dissertations about: "Decitabine"

Showing result 1 - 5 of 6 swedish dissertations containing the word Decitabine.

  2. 1. Regulation of DNA damage responses by the Myc oncogene : implications for future anti-cancer therapies

    Author : Andreas Höglund; Jonas Nilsson; Thomas Helleday; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Myc; DNA damage; Decitabine; Chk1; Chk2; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Myc is a transcription factor frequently found deregulated in human cancer. Cells with deregulated expression of Myc carry a selective advantage against its neighbours due to the fact that Myc-mediated transcription governs crucial cellular events such as proliferation and growth. READ MORE

  4. 2. Assessment of therapeutic targets in experimental models of Myc-induced lymphoma

    Author : Linus Plym Forshell; Jonas Nilsson; Lars-Gunnar Larsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Myc; Decitabine; Pim kinase; RCAS-tva; Neurobiology; Neurobiologi; molekylärbiologi; Molecular Biology;

    Abstract : The Myc transcription factor activates expression of genes that promote cellular functions such as proliferation and cell growth. The deregulated Myc expression, characteristic for the tumor cell, also activates apoptosis, which selects for additional genetic changes deactivating the induced cell death. READ MORE

  5. 3. Exploiting nucleotide metabolism to improve cancer therapy : by targeting dUTPase, dCTPase and NUDT15

    Author : Anna Hagenkort; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Synthetic nucleobase- and nucleoside-analogs have stood the test of time and remain a cornerstone in the treatment regimen against various forms of cancer. Due to their resemblance to endogenous nucleotides these antimetabolites interfere with cellular pathways, including nucleotide metabolism, as well as DNA and RNA synthesis. READ MORE

  6. 4. DNA methylation in T cell leukaemia

    Author : Maike Bensberg; Colm Nestor; Maria Jenmalm; Sofie Degerman; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : T cell acute lymphoblastic leukaemia (T-ALL) is a predominantly paediatric cancer that stems from malignant transformation of developing T cells. While the disease has an overall survival rate of 80%, the intense chemotherapy treatment causes severe toxicity and long-term side effects. READ MORE

  7. 5. Mechanistic studies of APR-246 in leukemia

    Author : Dina Mahmoud Ali; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : PRIMA-1 and its analog APR-246 are novel drugs that restore the active conformation of mutated and unfolded p53 protein and induce apoptosis and cell death in various tumors in pre-clinical models. We first aimed to explore the effects of APR-246 alone and in combination with other drugs in acute myeloid leukemia (AML) in vitro. READ MORE