Search for dissertations about: "Dermatan sulfate"

Showing result 6 - 10 of 13 swedish dissertations containing the words Dermatan sulfate.

  2. 6. Glycosaminoglycan Biosynthesis in Zebrafish

    Author : Beata Filipek-Górniok; Lena Kjellén; Johan Ledin; Kay Grobe; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparan sulfate; chondroitin dermatan sulfate; biosynthesis; development; N-deacetylase N-sulfotransferase; glycosyltransferases; morpholino; CRISPR-Cas9;

    Abstract : Proteoglycans (PGs) are composed of highly sulfated glycosaminoglycans chains (GAGs) attached to specific core proteins. They are present in extracellular matrices, on the cell surface and in storage granules of hematopoietic cells. READ MORE

  4. 7. FROM GENE TO STRUCTURE: Formation of Iduronic Acid in Dermatan Sulfate by Two DS-epimerases

    Author : Benny Pacheco; Matrixbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : During embryonic development and adult life a wide range of cell behaviors such as differentiation, proliferation and migration are in effect to maintain tissue integrity and function. An integral part of these dynamic processes is the interplay between the cells and their environment, i.e. the extracellular space. READ MORE

  5. 8. Glycosaminoglycan Biosynthesis and Function in Zebrafish Development : Sugars Shaping Skeletons

    Author : Judith Habicher; Johan Ledin; Per Erik Ahlberg; Marion Kusche-Gullberg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Heparan sulfate (HS) and chondroitin/dermatan sulfate (CS/DS) proteoglycans are glycosylated proteins with important roles in animal development and homeostasis. HS and CS/DS are long, linear glycosaminoglycan (GAG) polysaccharides and attached to a core protein they form proteoglycans. READ MORE

  6. 9. Fatty acids induce potentially atherogenic changes in extracellular matrix proteoglycans

    Author : Mariam Rodríguez-Lee; Göteborgs universitet; []
    Keywords : proteoglycans; glycosaminoglycans; fatty acids; smooth muscle cells; hepatocytes; LDL binding; remnant clearance; insulin resistance; type 2 diabetes;

    Abstract : Insulin resistance and type 2 diabetes (T2D) are associated with an increased prevalence of atherosclerotic cardiovascular disease (CVD). A key step in the initiation of atherogenesis is retention of low density lipoproteins (LDL) in the intima by chondroitin sulfate (CS)-rich proteoglycans (PG). READ MORE

  7. 10. Proteoglycans, group IIA phospholipase A2, and lipoproteins.Potential involvement in atherogenesis

    Author : Peter Sartipy; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atherosclerosis; group IIA phospholipase A2; proteoglycans; lipoproteins; inflammation;

    Abstract : Atherosclerosis is a multifactorial complex disease characterized by a focal accumulation of ApoB-100 containing lipoproteins, extracellular matrix (ECM), and cells in the arterial intima accompanied by an inflammatory reaction. In vivo and in vitro data supports the hypothesis that sulfated extracellular proteoglycans may be responsible for the selective retention of low density lipoproteins (LDL) in the arterial wall. READ MORE