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Showing result 1 - 5 of 27 swedish dissertations matching the above criteria.

2. 1. Applications of nanospray desorption electrospray ionization mass spectrometry : In situ lipid and metabolite analysis from cells to tissue

   Author : Hilde-Marléne Bergman; Ingela Lanekoff; Jonas Bergquist; Martina Marchetti-Deschmann; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; mass spectrometry imaging MSI ; nanospray desorption electrospray ionization nano-DESI ; single-cell analysis; neurotransmitter imaging; diabetic nephropathy; pneumatic nebulization; lipidomics; metabolomics; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Abstract : Ambient mass spectrometry (MS) has proved to be an important addition to the bioanalytical toolbox. These methods perform analyte sampling and ionization under atmospheric pressure, and require very little sample preparation other than the sampling process in front of the machine. READ MORE

4. 2. Applications of nanospray desorption electrospray ionization mass spectrome : Analysis of lipids and metabolites in brain tissue sections and single cells

   Author : Hilde-Marléne Bergman; Ingela Lanekoff; Jonas Bergquist; Leopold Ilag; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Nano-DESI; single cell analysis; small molecule neurotransmitters; mass spectrometry imaging; MSI; GABA; Glutamate; Acetylcholine; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Abstract : .... READ MORE

5. 3. Electrophoretic focusing in microchannels combined with mass spectrometry : Applications on amyloid beta peptides

   Author : Saara Mikkonen; Åsa Emmer; Johan Jacksén; Tapio Kotiaho; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; amyloid beta; computer simulation; electrophoresis; electrospray ionization; isoelectric focusing; isotachophoresis; MALDI; mass spectrometry; microchannel; microchip; nano-electrospray ionization; preconcentration; separation; Kemi; Chemistry;

   Abstract : Analysis of low-abundance components in small samples remains a challenge within bioanalytical chemistry, and new techniques for sample pretreatments followed by sensitive and informative detection are required. In this thesis, procedures for preconcentration and separation of proteins and peptides in open microchannels fabricated on silicon microchips are presented. READ MORE

6. 4. New Materials and Improved Ambient Techniques in Mass Spectrometry

   Author : Nicolò Riboni; Leopold Ilag; Elisa Robotti; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry; Solid Phase Microextraction; Ambient Mass Spectrometry; Desorption Electrospray Ionization; Paper Spray Ionization; Cavitands; BTEX; New Psychoactive Substances; Analytical Chemistry; analytisk kemi;

   Abstract : Mass spectrometry (MS) is used in several fields, e.g. biology, environmental monitoring, medicine and forensics due to excellent qualitative and quantitative capabilities. The development of new instrumental setups and ionization sources is crucial to analyze a variety of compounds at trace levels. READ MORE

7. 5. Novel strategies to increase throughput and differentiate lipid isomers in mass spectrometry imaging : Development of computational tools and complex mass spectrometric methods for nanospray desorption electrospray ionization

   Author : Johan Lillja; Ingela Lanekoff; Daniel Globisch; Orešič Matej; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; Mass spectrometry imaging; Tandem mass spectrometry; Silver cationization; Mathematical modeling; Lipid; Lipid isomer; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

   Abstract : In this thesis, method development for improved analyte identification and throughput in mass spectrometry imaging (MSI) is discussed. In MSI, the spatial distribution of analytes from a sample is determined and visualized, information about the detected molecules interaction within the sample can thereby the deduced. READ MORE