Search for dissertations about: "Desorption Electrospray Ionization"

Showing result 16 - 20 of 27 swedish dissertations containing the words Desorption Electrospray Ionization.

  2. 16. Development and Application of Software Tools for Mass Spectrometry Imaging

    Author : Patrik Källback; Per E. Andrén; Per Svenningsson; Anna Nilsson; Benjamin Bowen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; MALDI; DESI; msIQuant; quantitation; neurotransmitters; drugs; derivatization; brain; compression; data entropy reduction;

    Abstract : Mass spectrometry imaging (MSI) has been extensively used to produce qualitative maps of distributions of proteins, peptides, lipids, neurotransmitters, small molecule pharmaceuticals and their metabolites directly in biological tissue sections. Moreover, during the last 10 years, there has been growing demand to quantify target compounds in tissue sections of various organs. READ MORE

  4. 17. Advanced Mass Spectrometry Imaging in Neuropharmacology

    Author : Theodosia Vallianatou; Per E. Andrén; Anna Nilsson; Mohammadreza Shariatgorji; Maria Karlgren; Irena Loryan; Nathalie Agar; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; neuropharmacology; blood brain barrier; drug-drug interactions; aging; tacrine;

    Abstract : Mass spectrometry imaging (MSI) has emerged as a valuable approach for mapping multiple molecular species in sections of diverse tissues. It enables simultaneous detection of numerous compounds (from neurotransmitters to small proteins) in the brain at relatively high lateral resolution (>5 μm) on a routine basis. READ MORE

  5. 18. Microfluidic electrocapture in proteomic sample preparation for mass spectrometry

    Author : Susanne Vollmer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Proteomics is a technology-driven discipline and very labor-intensive. Over the last couple of years, methods with microfluidic systems have been used to simplify analytical procedures via integration of laboratory processes and equipment into miniaturized formats to achieve reproducible and high throughput analyses of biomolecules. READ MORE

  6. 19. Development of Liquid-based Separation Techniques using Tailored Surfaces for Analysis of Biological Samples

    Author : Emilia Hardenborg; Jonas Bergquist; Marit Andersson; Alejandro Cifuentes; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; aqueous humor; biological samples; capillary electrophoresis; coatings; drugs; liquid chromatography; molecular imprinted polymers; peptides; proteins; pseudoexfoliation; Analytical chemistry; Analytisk kemi;

    Abstract : Development and improvement of analytical techniques are vital in analytical chemistry research. This thesis describes the development and use of tailored surfaces for bioanalytical applications. READ MORE

  7. 20. Functional Proteome analysis of the molecular mechanism of (myo)fibroblast differentiation

    Author : Johan Malmström; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fibroblast myofibroblast extracellular matrix asthma COPD PDGF TGF-beta heparan sulfate proteoglycans proteomics mass spectrometry MALDI ESI; Metabolism; Biochemistry; Biokemi; metabolism;

    Abstract : Tissue remodeling is observed in several physiological conditions such as embryogenesis, senescence, wound healing and pregnancy, as well as in several pathological conditions such as fibrosis and tumorgenesis. Fibroblasts play a key role in this tissue remodeling due to their capability of altering the turnover of the extracellular matrix. READ MORE