Advanced search

Showing result 1 - 5 of 21 swedish dissertations matching the above criteria.

2. 1. Cellular transport and secretion of the cyanobacterial neurotoxin BMAA into milk and egg : Implications for developmental neurotoxicity

   Author : Marie Andersson; Ingvar Brandt; Cynthia de Wit; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; BMAA; beta-N-methylamino-L-alanine; milk; secretion; amino acid transporter; autoradiography; metabolism; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

   Abstract : The cyanobacterial amino acid β-N-methylamino-L-alanine (BMAA) is a neurotoxin implicated in the etiology of neurodegenerative diseases. Cyanobacteria are cosmopolitan organisms present in various environments. READ MORE

4. 2. Developmental Neurotoxicity of Environmental Pollutants : Effects on neuronal protein markers after neonatal exposure

   Author : Iwa Lee; Henrik Viberg; Elena Jazin; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental neurotoxicity; Neonatal exposure; Protein markers; Environmental pollutants; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

   Abstract : This thesis focused on investigations of the developmental neurotoxic effects of bisphenol A (BPA) or perfluorohexane sulfonate (PFHxS), after a single neonatal exposure, during a critical period of the brain development in mice.BPA is a well-known industrial chemical used in the production of polymer products and PFHxS is used as an industrial additive as a surfactant. READ MORE

5. 3. Novel Endpoints To Unravel Developmental Neurotoxicity : From DNA methylation responses to methylmercury to the in vitro identification of endocrine disruptors

   Author : Andrea Cediel-Ulloa; Joëlle Rüegg; Pamela J. Lein; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Developmental neurotoxicity; Methylmercury; DNA methylation; Endocrine disruptors; in vitro assay development; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

   Abstract : The developing brain is especially sensitive to environmental stressors due to its dependence on the precise spatiotemporal regulation of multiple signals, and the long time period required for its formation. Some chemicals can interfere with molecular and cellular processes driving brain development, including epigenetic processes such as DNA methylation. READ MORE

6. 4. Proteomic Characterization of Induced Developmental Neurotoxicity

   Author : Henrik Alm; Lennart Dencker; R Stuart Cobb; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; Brain Development; Neurotoxicity; 2D-DIGE; Brain Growth Spurt; Polybrominated Diphenyl Ether; Neonatal; Striatum; Hippocampus; Cerebral Cortex; Parkinsonism; Dyskinesia; Toxicology; Toxikologi; Toxicology; Toxikologi;

   Abstract : The developing brain goes through a number of developmental periods during which it displays an increased sensitivity to exogenous disturbances. On such period is the so called “Brain growth spurt” (BGS) which in humans takes place starting from the third trimester of pregnancy and throughout the first few years of life. READ MORE

7. 5. Developmental Neurotoxicity in Mice Neonatally Co-exposed to Environmental Agents : PCB, PBDE, Methyl Mercury and Ionized Radiation - Interactions and Effects

   Author : Celia Fischer; Per Eriksson; Anders Fredriksson; Richard Seegal; Uppsala universitet; []
   Keywords : Biology; PCB; PBDE; MeHg; ionized radiation; neonatal; development; neurotoxicity; behavior; cholinergic system; Biologi;

   Abstract : This thesis investigates the neurotoxic effects in mice neonatally co-exposed to different toxic environmental agents during a defined critical period of the brains's rapid growth and development. Environmental toxic agents are incorporated in our environment. READ MORE