Search for dissertations about: "Developmental toxicology"

Showing result 21 - 25 of 26 swedish dissertations containing the words Developmental toxicology.

  2. 21. Investigating mechanisms of angiogenesis in health and disease using zebrafish models

    Author : Zaheer Ali; Lasse D. Jensen; Neil Lagali; Massimo Santoro; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Angiogenesis, the growth of blood vessels from an existing vasculature, can occur by sprouting from preexisting vessels or by vessel splitting (intussusception). Pathological angiogenesis drives choroidal neovascularization (CNV) in age related macular degeneration (AMD) which is commonly restricted under the retinal pigment epithelium (RPE), called occult CNV, but may also involve vessels penetrating through the RPE into the sub-retinal space. READ MORE

  4. 22. In vitro developmental neurotoxicity of acrylamide

    Author : Kristina Attoff; Anna Forsby; Ann-Kristin Östlund Farrants; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The number of children with neurodevelopmental disorders is increasing worldwide which makes it a public concern. Exposure to environmental chemicals has been reported as a source of developmental neurotoxicity. READ MORE

  5. 23. Developmental neurotoxicity of persistent and non-persistent pollutants : Behavioral and neurochemical assessments of a perfluorinated compound, pesticides and interaction effects

    Author : Iwa Lee; Henrik Viberg; Per Eriksson; William Mundy; Uppsala universitet; []
    Keywords : Brain; Neonatal; Mixtures; Cholinergic system; Organochlorines; Pyrethroids; Organophosphates; Carbamates; Insecticides; PFCs; PFAAs; PFHxS; Endosulfan; Cypermethrin; Chlorpyrifos; Carbaryl; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Abstract : The focus of this thesis was to investigate developmental neurotoxic effects of different persistent and non-persistent environmental pollutants, alone or in binary mixtures, when exposure occurs during a critical period of brain development, in mice. The compounds investigated included a perfluorinated compound, perfluorohexane sulphonate (PFHxS), and four different pesticides, endosulfan, cypermethrin, chlorpyrifos and carbaryl. READ MORE

  6. 24. Neurodevelopmental Consequences of Exposure to Paracetamol (Acetaminophen) and Related Drugs : Experimental studies in mice

    Author : Gaëtan Philippot; Robert Fredriksson; Vesna Jevtovic-Todorovic; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; paracetamol acetaminophen ; developmental neurotoxicology; delta9-tetrahydrocannabinol THC ; ibuprofen; endocannabinoid system; neonatal mice; brain growth spurt; behavior; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Abstract : Paracetamol (acetaminophen) is the analgesic pharmaceutical most commonly used during pregnancy and early life. While therapeutic doses of paracetamol are considered harmless during these periods, recent findings in both humans and rodents suggest a link between developmental exposure to paracetamol and behavioral consequences later in life. READ MORE

  7. 25. Developmental and Reproductive Toxicity of Progestagens in the Xenopus (Silurana) tropicalis Test System

    Author : Moa Säfholm; Cecilia Berg; Ingvar Brandt; Jan Olsson; Louis Guillette; Uppsala universitet; []
    Keywords : Xenopus tropicalis; sex organ differentiation; oogenesis; fertility; ovary; oviduct; progestagens; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Abstract : Progestagenic compounds are emerging contaminants found in surface and ground water around the world. Information on the effects and potency of progestagens is needed in order to understand the environmental risks posed by these compounds. READ MORE