Search for dissertations about: "Diabetes - öcellsexocytos"

Showing result 1 - 5 of 8 swedish dissertations containing the words Diabetes - öcellsexocytos.

  2. 1. Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion

    Author : Sofia A Andersson; Diabetes - öcellsexocytos; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Insulin; Glucagon; Alpha-cells; Beta-cells; Exocytosis; Capacitance; SNARE; SNAP25; Syntaxin1A; Synaptotagmin; Munc-18 Stxbp1 ; SNP; Expression; miRNA;

    Abstract : Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). READ MORE

  4. 2. Answers of big biological data to unsolved diabetes questions - Unveiling causes of impaired β-cell insulin secretion

    Author : Alexandros Karagiannopoulos; Diabetes - öcellsexocytos; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoids; beta cell; miRNA; type 2 diabetes; insulin secretion; bioinformatics;

    Abstract : .... READ MORE

  5. 3. Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function

    Author : Vishal Ashok Salunkhe; Diabetes - öcellsexocytos; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; exocytosis; Ca2 ; miR-375; miR-335; rosuvastatin; voltage-gated Na channels; STXBP1; SNAP25; SYT11; glucose homeostasis; beta cell function;

    Abstract : Type 2 diabetes (T2D) is a condition of high blood glucose levels due to insulin resistance and defective insulin secretion. Impaired insulin secretion plays a major role in the pathophysiology of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. READ MORE

  6. 4. Exocytosis in insulin secreting cells - role of SNARE-proteins

    Author : Jenny Vikman; Diabetes - öcellsexocytos; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; calcium channel; cAMP; syntaxin 1; SNAP-25; SNARE; exocytosis; Insulin secretion; pancreatic beta-cells;

    Abstract : Type 2 diabetes is marked by deterioration in pancreatic β-cell function. SNARE-proteins are crucial for the fusion of insulin granules with the plasma membrane, a prerequisite for insulin secretion. READ MORE

  7. 5. GABA in the islets of Langerhans

    Author : Anna Wendt; Diabetes - öcellsexocytos; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; diabetologi; sekretion; Endokrinologi; Endocrinology; SLMV; paracrine regulation; LDCV; islets of Langerhans; autocrine regulation; GABA; diabetology;

    Abstract : GABA (γ-aminobutyric acid) is a well-known inhibitory neurotransmitter in the CNS. GABA is also present at high concentrations in the insulin-producing β-cells in the islets of Langerhans, but its function there is less clear. GABA is believed to accumulate in SLMVs (synaptic-like microvesicles). READ MORE