Search for dissertations about: "Diabetes - Immunovirologi"
Showing result 1 - 5 of 6 swedish dissertations containing the words Diabetes - Immunovirologi.
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1. Beta Cell Function: from Human Genetics to Animal Models
Abstract : Beta cell function is an important factor in the development of both Type 1 (T1D) and Type 2 (T2D) diabetes mellitus. T1D is characterized by a primary defect in insulin secretion due to the immune-mediated beta cell destruction, however, the more common T2D beside insulin resistance also include impaired beta cell function as a consequence to abnormal glucose homeostasis. READ MORE
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2. Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors
Abstract : Tolerance is crucial for maintaining immunological balance and avoid autoimmune diseases like type 1 diabetes and the inflammatory bowel disease, ulcerative colitis (UC). In Study I, we have investigated the regulatory role of a class of noncoding RNAs, the miRNAs, during thymocyte development of the where central tolerance is established. READ MORE
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3. Cellular Immunological Mechanisms Contributing to Diabetes Pathogenesis
Abstract : .... READ MORE
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4. Aspects of T cell development contributing to autoimmunity
Abstract : Autoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. READ MORE
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5. On the induction and function of Foxp3+ regulatory T cells
Abstract : This thesis is based on three original papers with the overall aim to study the mechanisms of induction and function of Foxp3+CD4+CD25+ regulatory T cells. Regulatory T cells induce down-modulation of costimulatory molecules CD80 and CD86 on dendritic cells in vitro. READ MORE