Search for dissertations about: "Diabetes Insulin Resistance Obesity"

Showing result 1 - 5 of 159 swedish dissertations containing the words Diabetes Insulin Resistance Obesity.

2. 1. Insulin signalling in human adipocytes : mechanisms of insulin resistance in type 2 diabetes

   Author : Anna Danielsson; Peter Strålfors; Fredrik Nyström; Lena Stensson; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocytes; type 2 diabetes; insulin; insulin resistance; insulin signalling; phosphorylation; insulin receptor substrate 1; feedback control; Medical cell biology; Medicinsk cellbiologi;

   Abstract : Prevalensen av fetma ökar drastiskt i stora delar av världen och utgör en stor riskfaktor för att utveckla insulinresistens och typ 2 diabetes. Fettväven kan bli mycket stor om för mycket energi tas upp av kroppen. READ MORE

4. 2. FOXC2 and CAPN10 as candidate genes for obesity, insulin resistance and type 2 diabetes

   Author : Emma A Nilsson; diabetes och endokrinologi Genomik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper; Biomedical sciences; Type 2 diabetes; Genetics; Obesity;

   Abstract : The worldwide prevalence of obesity and type 2 diabetes is increasing rapidly. Both disorders depend on genetic and environmental factors. The studies included in this thesis investigated the possible association of the FOXC2 and CAPN10 genes with obesity, insulin resistance, type 2 diabetes, and related phenotypes. READ MORE

5. 3. Genetic and Metabolic Markers for the Development of Diabetes after Gestational Diabetes Mellitus

   Author : Magnus Ekelund; diabetes och endokrinologi Genomik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oral glucose tolerance tests; Genetics; Autoimmunity; Insulin sensitivity; Gestational diabetes mellitus; Insulin secretion; HbA1c; Fasting glucose; FTO-gene; Postpartum diabetes;

   Abstract : The aims of this work were to determine the prevalence of postpartum diabetes among women with gestational diabetes mellitus (GDM) in a prospective study 5 years postpartum; to characterize these women according to insulin secretion, insulin sensitivity, autoimmunity and genetics; and to identify possible markers and predictors for the development of manifest diabetes. The subjects were recruited through a regional screening programme in which oral glucose tolerance tests (OGTTs) are routinely offered to all pregnant women. READ MORE

6. 4. Insulin-antagonistic neurohormonal pathways in the development of insulin resistance and type 2 diabetes

   Author : Martin Lundqvist; Jan W Eriksson; Niclas Abrahamsson; André van Beek; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucagon; cortisol; ACTH; growth hormone; counter-regulation; clamp; hypoglycemia; hyperglycemia; obesity; type 2 diabetes; inflammation;

   Abstract : According to the current paradigm, the development of type 2 diabetes is driven by insulin resistance and the gradual failure of beta cells to compensate for this by secreting adequate amounts of insulin. Obesity is an important risk factor for type 2 diabetes and is considered to influence disease development primarily by induction of insulin resistance, via mechanisms that have not been fully elucidated. READ MORE

7. 5. Semi-mechanistic models of glucose homeostasis and disease progression in type 2 diabetes

   Author : Steve Choy; Maria Kjellsson; Mats Karlsson; Willem de Winter; Andrea Mari; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; pharmacometrics; glucose homeostasis; insulin; type 2 diabetes; obesity; weight; visceral adipose tissue; HbA1c; non-linear mixed effects; modelling; disease progression; ZDSD rats; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by consistently high blood glucose, resulting from a combination of insulin resistance and reduced capacity of β-cells to secret insulin. While the exact causes of T2DM is yet unknown, obesity is known to be a major risk factor as well as co-morbidity for T2DM. READ MORE