Search for dissertations about: "Diabetic model"

Showing result 1 - 5 of 175 swedish dissertations containing the words Diabetic model.

  2. 1. Covariate Model Building in Nonlinear Mixed Effects Models

    Author : Jakob Ribbing; E. Niclas Johnsson; Mats O. Karlsson; Janet Wade; Uppsala universitet; []
    Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Modeling; Covariate selection; Stepwise selection; Covariate analysis; Methodology; Model validation; Model evaluation; Type-2 diabetes; Beta-cell function; Meta analysis; Cross-validation; Least absolute shrinkage and selection operator; Pharmacometrics; ED optimization; Farmakokinetik Farmakoterapi;

    Abstract : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. READ MORE

  4. 2. Factors influencing the risk of diabetic nephropathy : analyses of genes, smoking and diet

    Author : Anna Möllsten; Gisela Dahlquist; Lise Tarnow; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 1 diabetes; diabetic nephropathy; oxidative stress; smoking; diet; blood pressure; renin-angiotensin system; nitric oxide synthase; Kidney diseases; Njursjukdomar;

    Abstract : Diabetic long-term complications, despite intensive treatment, cause serious handicaps at relatively young age in diabetic patients. Diabetic nephropathy (DN) develops in up to 30% of patients with type 1 diabetes (T1D). READ MORE

  5. 3. Gene therapy in a new model of delayed wound healing

    Author : Patrik Velander; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IGF-1; Gene therapy; Diabetes; Animal model; EGF;

    Abstract : Diabetes wounds result in significant morbidity, prolonged hospitalization and huge health care expenses. As of yet, no optimal animal models of diabetic wound healing exist to study potential beneficial therapies. Porcine wound healing is very similar to human wound healing. READ MORE

  6. 4. Microencapsulation of Pancreatic Islets : A Non-Vascularised Transplantation Model

    Author : Sara Bohman; Arne Andersson; Aileen King; Stellan Sandler; Eduard Montanya; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microencapsulation; Islet transplantation; revascularisation; alpha-cell; exendin-4; islet amyloid; Cell biology; Cellbiologi;

    Abstract : Transplantation of pancreatic islets is a potential treatment of type 1 diabetes that aims to restore normal blood glucose control. By encapsulating the islets in alginate, they can be protected from rejection. READ MORE

  7. 5. Spatial analysis and modeling of nerve fiber patterns

    Author : Claes Andersson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hierarchical models; Bayesian estimation; epidermal nerve fibers; cluster processes; spatial point processes; diabetic neuropathy; Bayesian field theory; Diabetic neuropathies; Multilevel models Statistics ; Institutionen för matematiska vetenskaper. Tillämpad matematik och statistik.; CTH;

    Abstract : Diabetic neuropathy is a condition associated with diabetes affecting the epidermal nerve fibers (ENFs). This thesis presents analysis methods and models for ENF data, with two main puroposes: to find early signs of diabetic neuropathy and to characterize how this condition changes the nerve fiber structure. READ MORE