Search for dissertations about: "Diarmaid Hughes"

Showing result 11 - 15 of 19 swedish dissertations containing the words Diarmaid Hughes.

  2. 11. The Physiological Cost of Antibiotic Resistance

    Author : Mirjana Macvanin; Diarmaid Hughes; Stanley Maloy; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; fusidic acid; fitness cost; protein synthesis; EF-G; ppGpp; RpoS; oxidative stress; heme; Mikrobiologi; Microbiology; immunology; infectious diseases; Mikrobiologi; immunologi; infektionssjukdomar;

    Abstract : Becoming antibiotic resistant is often associated with fitness costs for the resistant bacteria. This is seen as a loss of competitiveness against the antibiotic-sensitive wild-type in an antibiotic-free environment. READ MORE

  4. 12. Resistance to Fluoroquinolones in Escherichia coli: Prevention, Genetics and Fitness Costs

    Author : Linda L. Marcusson; Diarmaid Hughes; Karl Drlica; Uppsala universitet; []
    Keywords : Biology; Fluoroquinolone; Escherichia coli; Resistance; Gyrase; Topoisomerase IV; MPC; Fitness compensation; Urinary Tract Infection; Biologi;

    Abstract : Antibiotic-resistant bacteria are increasingly a major healthcare problem but very few new classes of antibiotics have been discovered or launched in recent decades. Approaches to dealing with the problem include learning how bacteria evolve to resistance and improving dosing regimens with current antibiotics so as to reduce the selection of resistant bacteria. READ MORE

  5. 13. On Fusidic Acid Resistance in Staphylococcus Aureus

    Author : Tobias Norström; Diarmaid P. Hughes; Bruce R. Levin; Uppsala universitet; []
    Keywords : Microbiology; S. aureus; SCV; fusidic acid; FusE; Mikrobiologi;

    Abstract : Controlling bacterial infections with antibiotics is central to modern health care. However, increasing bacterial resistance to antibiotics threatens effective therapy. This thesis concerns the use of the antibiotic fusidic acid, and novel analogues of fusidic acid, to treat topical infections caused by the bacterial pathogen Staphylococcu aureus. READ MORE

  6. 14. Relation Between Drug Exposure and Selection of Antibiotic Resistant Bacteria

    Author : Sara K. Olofsson; Otto Cars; Dan I. Andersson; Diarmaid Hughes; George G. Zhanel; Uppsala universitet; []
    Keywords : Microbiology; Pharmacokinetics; Pharmacodynamics; Antibiotic resistance; Selection; Transmission; Mathematical model; Escherichia coli; Mikrobiologi;

    Abstract : The worldwide increase in antibiotic resistance is a concern for public health. When the appropriate antibiotic dosage is determined, the priorities are efficacy and toxicity. The aim of this thesis was to gain knowledge about the most efficient dosing regimens in order to minimize the emergence and selection of antibiotic-resistant mutants. READ MORE

  7. 15. Evolution of Antibiotic Resistance

    Author : Franziska Pietsch; Diarmaid Hughes; Josep Casadesús; Uppsala universitet; []
    Keywords : ciprofloxacin; rifampicin; bacterial fitness; compensation; mutation rate; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Abstract : The emergence of antimicrobial resistance is a major global threat to modern medicine. The rapid dissemination of resistant pathogens and the associated loss of efficacy of many important drugs needs to be met with the development of new antibiotics and alternative treatment options. READ MORE