Search for dissertations about: "Diels-Alderase"

Found 2 swedish dissertations containing the word Diels-Alderase.

2. 1. Biosynthetic and synthetic studies of the fungal metabolite galiellalactone

   Author : Martin H Johansson; Centrum för analys och syntes; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Bioteknik; Organisk kemi; Organic chemistry; enzyme; mycelium; intramolecular Diels-Alder reaction; Diels-Alderase; asymmetric synthesis; biosynthesis; total synthesis; STAT3 inhibition; galiellalactone; fungal metabolite;

   Abstract : Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. READ MORE

4. 2. Computational Studies and Design of Biomolecular Diels-Alder Catalysis

   Author : Mats Linder; Tore Brinck; Kendall N. Houk; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Computational chemistry; density functional theory; enzyme design; molecular modeling; organocatalysis; stepwise Diels-Alder; oxyanion hole;

   Abstract : The Diels-Alder reaction is one of the most powerful synthetic tools in organic chemistry, and asymmetric Diels-Alder catalysis allows for rapid construction of chiral carbon scaffolds. For this reason, considerable effort has been invested in developing efficient and stereoselective organo- and biocatalysts. READ MORE